A proposal for a rat model of spinal cord injury featuring the rubrospinal tract and its contributions to locomotion and skilled hand movement

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dc.contributor.authorMorris, Renee
dc.contributor.authorWhishaw, Ian Q.
dc.date.accessioned2017-10-18T21:02:07Z
dc.date.available2017-10-18T21:02:07Z
dc.date.issued2016
dc.descriptionSherpa Romeo green journal: open accessen_US
dc.description.abstractSpinal cord injury and repair is a dynamic field of research. The development of reliable animal models of traumatic spinal cord injury has been invaluable in providing a wealth of information regarding the pathological consequences and recovery potential of this condition. A number of injury models have been instrumental in the elaboration and the validation of therapeutic interventions aimed at reversing this once thought permanent condition. In general, the study of spinal cord injury and repair is made difficult by both its anatomical complexity and the complexity of the behavior it mediates. In this perspective paper, we suggest a new model for spinal cord investigation that simplifies problems related to both the functional and anatomical complexity of the spinal cord. We begin by reviewing and contrasting some of the most common animal models used for investigating spinal cord dysfunction. We then consider two widely used models of spinal deficit-recovery, one involving the corticospinal tracts (CTS) and the other the rubrospinal tract (RST). We argue that the simplicity of the function of the RST makes it a useful model for studying the cord and its functional repair. We also reflecton two obstacles that have hindered progress in the pre-clinical field, delaying translation to the clinical setup. The first is recovery of function without reconnection of the transected descending fibers and the second is the use of behavioral paradigms that are not under the control of the descending fiber pathway under scrutiny.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationMorris, R., & Whishaw, I. Q. (2016). A proposal for a rat model of spinal cord injury featuring the rubrospinal tract and its contributions to locomotion and skilled hand movement. Frontiers in Neuroscience, 10: 5. doi:10.3389/fnins.2016.00005en_US
dc.identifier.urihttps://hdl.handle.net/10133/4937
dc.language.isoen_USen_US
dc.publisherFrontiers Mediaen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.subjectRubrospinal tracten_US
dc.subjectSkilled reachingen_US
dc.subjectSpinal cord injuryen_US
dc.subjectSpinal cord repairen_US
dc.subjectArpeggioen_US
dc.subjectSpinal deficit-recoveryen_US
dc.subject.lcshSpinal cord
dc.subject.lcshSpinal cord--Wounds and injuries
dc.subject.lcshPyramidal tract
dc.subject.lcshRats as laboratory animals
dc.titleA proposal for a rat model of spinal cord injury featuring the rubrospinal tract and its contributions to locomotion and skilled hand movementen_US
dc.typeArticleen_US
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