Acute NMDA receptor antagonism disrupts synchronization of action potential firing in rat prefrontal cortex

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dc.contributor.authorMolina, Leonardo A.
dc.contributor.authorSkelin, Ivan
dc.contributor.authorGruber, Aaron J.
dc.date.accessioned2017-01-17T19:51:51Z
dc.date.available2017-01-17T19:51:51Z
dc.date.issued2014
dc.descriptionSherpa Romeo green journal; open accessen_US
dc.description.abstractAntagonists of N-methyl-D-aspartate receptors (NMDAR) have psychotomimetic effects in humans and are used to model schizophrenia in animals. We used high-density electrophysiological recordings to assess the effects of acute systemic injection of an NMDAR antagonist (MK-801) on ensemble neural processing in the medial prefrontal cortex of freely moving rats. Although MK-801 increased neuron firing rates and the amplitude of gamma-frequency oscillations in field potentials, the synchronization of action potential firing decreased and spike trains became more Poisson-like. This disorganization of action potential firing following MK-801 administration is consistent with changes in simulated cortical networks as the functional connections among pyramidal neurons become less clustered. Such loss of functional heterogeneity of the cortical microcircuit may disrupt information processing dependent on spike timing or the activation of discrete cortical neural ensembles, and thereby contribute to hallucinations and other features of psychosis induced by NMDAR antagonists.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationMolina, L. A., Skelin, I., & Gruber, A. J. (2014). Acute NMDA receptor antagonism disrupts synchronization of action potential firing in rat prefrontal cortex. PLoS ONE, 9(1), e85842. doi:10.1371/journal.pone.0085842en_US
dc.identifier.urihttps://hdl.handle.net/10133/4761
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.subjectNMDAR antagonistsen_US
dc.subjectMK-801en_US
dc.subjectPrefrontal cortexen_US
dc.subjectSchizophreniaen_US
dc.subjectMethyl aspartate -- Antagonists -- Researchen_US
dc.subjectMethyl aspartate -- Receptors -- Researchen_US
dc.subjectRats as laboratory animalsen_US
dc.titleAcute NMDA receptor antagonism disrupts synchronization of action potential firing in rat prefrontal cortexen_US
dc.typeArticleen_US
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