Liver irradiation causes distal bystander effects in the rat brain and affects animal behavior

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dc.contributor.authorKovalchuk, Anna
dc.contributor.authorMychasiuk, Richelle
dc.contributor.authorMuhammad, Arif
dc.contributor.authorHossain, Shakhawat
dc.contributor.authorIlnytskyy, Slava
dc.contributor.authorGhose, Abhijit
dc.contributor.authorKirby, Charles
dc.contributor.authorGhasroddashti3, Esmaeel
dc.contributor.authorKovalchuk, Olga
dc.contributor.authorKolb, Bryan
dc.date.accessioned2019-01-23T21:26:27Z
dc.date.available2019-01-23T21:26:27Z
dc.date.issued2016
dc.descriptionSherpa Romeo blue journal. Open access: Creative Commons Attribution 3.0 License (CC BY 3.0) applies.en_US
dc.description.abstractRadiation therapy can not only produce effects on targeted organs, but can also influence shielded bystander organs, such as the brain in targeted liver irradiation. The brain is sensitive to radiation exposure, and irradiation causes significant neurocognitive deficits, including deficits in attention, concentration, memory, and executive and visuospatial functions. The mechanisms of their occurrence are not understood, although they may be related to the bystander effects. We analyzed the induction, mechanisms, and behavioural repercussions of bystander effects in the brain upon liver irradiation in a well-established rat model. Here, we show for the first time that bystander effects occur in the prefrontal cortex and hippocampus regions upon liver irradiation, where they manifest as altered gene expression and somewhat increased levels of fH2AX. We also report that bystander effects in the brain are associated with neuroanatomical and behavioural changes, and are more pronounced in females than in males.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationKovalchuk, A., Mychasiuk, R., Muhammad, A., Hossain, S., Ilnytskyy, S., Ghose, A.,...Kolb. B. (2016). Liver irradiation causes distal bystander effects in the rat brain and affects animal behavior. Oncotarget, 7(4), 4385-4398. https://doi.org/10.18632/oncotarget.6596en_US
dc.identifier.urihttps://hdl.handle.net/10133/5273
dc.language.isoen_USen_US
dc.publisherImpact Journalsen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.institutionAlberta Health Servicesen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.institutionAlberta Epigenetics Networken_US
dc.publisher.institutionCanadian Institute for Advanced Researchen_US
dc.publisher.urlhttps://doi.org/10.18632/oncotarget.6596
dc.subjectRadiation therapyen_US
dc.subjectBrainen_US
dc.subjectNeuroanatomyen_US
dc.subjectBehaviouren_US
dc.subjectGene expressionen_US
dc.subjectBystander effectsen_US
dc.subjectRat brainen_US
dc.subjectBystander organs
dc.subjectLiver irradiation
dc.subject.lcshRadiotherapy
dc.subject.lcshAnimal behavior--Research
dc.subject.lcshRats--Behavior
dc.titleLiver irradiation causes distal bystander effects in the rat brain and affects animal behavioren_US
dc.typeArticleen_US
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