Browsing Sutherland, Robert by Title

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  • Making context memories independent of the hippocampus 
    Lehmann, Hugo; Sparks, Fraser T.; Spanswick, Simon C.; Hadikin, Crystal; McDonald, Robert J.; Sutherland, Robert J. (Cold Spring Harbor Laboratory PressArts and ScienceDepartment of NeuroscienceTrent UniversityUniversity of Lethbridgehttps://dx.doi.org/10.1101/lm.1385409, 2009)
    We present evidence that certain learning parameters can make a memory, even a very recent one, become independent of the hippocampus. We confirm earlier findings that damage to the hippocampus causes severe retrograde ...
  • Mental rotational ability is correlated with spatial but not verbal working memory performance and P300 amplitude in males 
    Christie, Gregory J.; Cook, Charles M.; Ward, Brian J.; Tata, Matthew S.; Sutherland, Janice; Sutherland, Robert J.; Saucier, Deborah M. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeSimon Fraser UniversityUniversity of Ontario Institute of Technology, 2013)
    This study investigated how both sex and individual differences in a mental rotation test (MRT) influence performance on working memory (WM). To identify the neural substrate supporting these differences, brain electrical ...
  • A novel animal model of hippocampal cognitive deficits, slow neurodegeneration, and neuroregeneration 
    Spanswick, Simon C.; Lehmann, Hugo; Sutherland, Robert J. (Hindawi PublishingArts and ScienceDepartment of NeuroscienceUniversity of CalgaryTrent UniversityUniversity of Lethbridgehttps://dx.doi.org/10.1155/2011/527201, 2011)
    Long-term adrenalectomy (ADX) results in an extensive and specific loss of dentate gyrus granule cells in the hippocampus of adult rats. This loss of granule cells extends over a period of weeks to months and ultimately ...
  • Object/context-specific memory deficits associated with loss of hippocampal granule cells after adrenalectomy in rats 
    Spanswick, Simon C.; Sutherland, Robert J. (Cold Spring Harbor Laboratory PressArts and ScienceDepartment of NeuroscienceUniversity of Lethbridgehttps://dx.doi.org/10.1101/lm.1746710, 2010)
    Chronic adrenalectomy (ADX) causes a gradual and selective loss of granule cells in the dentate gyrus (DG) of the rat.Here, we administered replacement corticosterone to rats beginning 10wk after ADX. We then tested them ...
  • Suppression of neurotoxic lesion-induced seizure activity: evidence for a permanent role for the hippocampus in contextual memory 
    Sparks, Fraser T.; Lehmann, Hugo; Hernandez, Khadaryna; Sutherland, Robert J. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeTrent University, 2011)
    Damage to the hippocampus (HPC) using the excitotoxin N-methyl-D-aspartate (NMDA) can cause retrograde amnesia for contextual fear memory. This amnesia is typically attributed to loss of cells in the HPC. However, NMDA ...