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dc.contributor.author Wang, Justin
dc.contributor.author Wu, Chiping
dc.contributor.author Peng, Jessie
dc.contributor.author Patel, Nisarg
dc.contributor.author Huang, Yayi
dc.contributor.author Gao, Xiaoxing
dc.contributor.author Aljarallah, Salman
dc.contributor.author Eubanks, James H.
dc.contributor.author McDonald, Robert J.
dc.contributor.author Zhang, Liang
dc.date.accessioned 2019-01-22T23:06:12Z
dc.date.available 2019-01-22T23:06:12Z
dc.date.issued 2015
dc.identifier.citation Wang, J., Wu, C., Peng, J., Patel, N., Huang, Y., Gao, X.,...Zhang, L. (2015). Early-onset convulsive seizures induced by brain hypoxia-schemia in aging mice: Effects of anticonvulsive treatments. PLoS ONE, 10(12), e0144113. doi:10.1371/journal.pone.0144113 en_US
dc.identifier.uri https://hdl.handle.net/10133/5269
dc.description Sherpa Romeo green journal. Open access article. Creative Commons Attribution License applies. en_US
dc.description.abstract Aging is associated with an increased risk of seizures/epilepsy. Stroke(ischemic or hemorrhagic) and cardiac arrest related brain injury are two major causative factors for seizure development in this patient population. With either etiology, seizures area poor prognostic factor. In spite of this, the underlying pathophysiology of seizure development is not well understood. In addition, a standardized treatment regimen with anticonvulsants and outcome assessments following treatment has yet to be established for these post-ischemic seizures. Previous studies have modeled post-ischemic seizures in adult rodents, but similar studies in aging/aged animals, a group that mirrors a higher risk elderly population, remain sparse. Our study therefore aimed to investigate early-onset seizures in aging animals using a hypoxia-ischemia (HI) model. Male C57 black mice18-20-month-old underwent a unilateral occlusion of the common carotid artery followed by a systemic hypoxic episode (8% O2 for 30 min). Early-onset seizures were detected using combined behavioral and electroencephalographic (EEG) monitoring. Brain injury was assessed histologically at different times post HI. Convulsive seizures were observed in 65% of aging mice post-HI but not in control aging mice following either sham surgery or hypoxiaalone. These seizures typically occurred within hours of HI and behaviorally consisted of jumping, fast running, barrel-rolling, and/or falling (loss of the righting reflex) with limb spasms. No evident discharges during any convulsive seizures were seen on cortical-hippocampal EEG recordings. Seizure development was closely associated with acute mortality and severe brain injury on brain histological analysis. Intra-peritoneal injections of lorazepam and fosphenytoin suppressed seizures and improved survival but only when applied prior to seizure onset and not after. These findings together suggest that seizures are a major contributing factor to acute mortality in aging mice following severe brain ischemia and that early anticonvulsive treatment may prevent seizure genesis and improve overall outcomes. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.subject Early-onset seizures en_US
dc.subject Aging animals en_US
dc.subject Hypoxia-ischemia en_US
dc.subject Anticonvulsive treatments en_US
dc.subject Brain injury
dc.subject.lcsh Convulsions
dc.subject.lcsh Hypoxic-ischemic encephalopathy
dc.subject.lcsh Anticonvulsants
dc.subject.lcsh Mice--Aging
dc.title Early-onset convulsive seizures induced by brain hypoxia-ischemia in aging mice: effects of anticonvulsive treatments en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution Toronto Western Research Institute en_US
dc.publisher.institution University of Toronto en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.institution King Saud University en_US
dc.publisher.url https://dx.doi.org/10.1371/journal.pone.0144113


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