Factors influencing cerebral plasticity in the normal and injured brain

Thumbnail Image
Date
2010
Authors
Kolb, Bryan
Teskey, G. Campbell
Gibb, Robbin L.
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Research Foundation
Abstract
An important development in behavioral neuroscience in the past 20 years has been the demonstration that it is possible to stimulate functional recovery after cerebral injury in laboratory animals. Rodent models of cerebral injury provide an important tool for developing such rehabilitation programs. The models include analysis at different levels including detailed behavioral paradigms, electrophysiology, neuronal morphology, protein chemistry, and epigenetics. A significant challenge for the next 20 years will be the translation of this work to improve the outcome from brain injury and disease in humans. Our goal in the article will be to synthesize the multidisciplinary laboratory work on brain plasticity and behavior in the injured brain to inform the development of rehabilitation programs.
Description
Sherpa Romeo green journal: open access
Keywords
Brain plasticity , Recovery of function , Cerebral cortex , Brain--Wounds and injuries , Neuroplasticity , Brain damage--Animal models
Citation
Kolb, B., Teskey, G. C., & Gibb, R. (2010). Factors influencing cerebral plasticity in the normal and injured brain. Frontiers in Human Neuroscience, 4(204). doi:10.3389/fnhum.2010.00204