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Browsing by Author "Abbott, D. Wade"

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Butyrate, Bacteroides thetaiotaomicron and Campylobacter jejuni modulate the expression of beta-defensins, Toll-like receptors and cytokines in Caco-2 cells

Yamashita, Justin; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta : University of Lethbridge, Dept. of Chemistry and BiochemistryArts and ScienceDepartment of Chemistry & Biochemistry, 2016)

Dietary fibre fermentation produces short-chain fatty acids, including butyrate (NaB). NaB increases histone tail acetylation within the chromatin of colonic cells, a process associated with increased gene expression. ...
Characterization of NfGHX : a founding member of a new glycoside hydrolase family from the anaerobic fungus Neocallimastix frontalis

Uddin, Muhammed Salah; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta : University of Lethbridge, Dept. of Biological SciencesArts and ScienceDepartment of Biological Sciences, 2016)

The discovery and characterization of enzymes that catalyze new reactions, and increase the rate or efficiency of bioconversion are promising lines of biotechnological research. In this regard the rumen anaerobic fungi ...
Comparative variation within the genome of Campylobacter jejuni NCTC 11168 in human and murine hosts

Thomas, Dallas K.; Lone, Abdul G.; Selinger, L. Brent; Taboada, Eduardo N.; Uwiera, Richard R.E.; Abbott, D. Wade; Inglis, G. Douglas (Public LIbrary of ScienceArts and ScienceDepartment of Biological SciencesAgriculture and Agri-Food Canada Research CentreUniversity of LethbridgePublic Health Agency of CanadaUniversity of Alberta, 2014)

Campylobacteriosis incited by C. jejuni is a significant enteric disease of human beings. A person working with two reference strains of C. jejuni National Collection of Type Cultures (NCTC) 11168 developed symptoms ...
Direct visualization of yeast mannan metabolism in bovine-adapted Bacteroides thetaiotaomicron strains at the single cell level using fluoresceinamine - yeast mannan conjugates

Klassen, Leeann; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : Universtiy of Lethbridge, Department of Biological SciencesArts and ScienceDepartment of Biological Sciences, 2019)

The rumen of beef cattle houses a diverse community of microorganisms that impact feed digestion, nutrient accessibility, host health, and waste production. Fibrolytic enzymes, probiotics, and prebiotics are promising ...
Engineering dual-glycan responsive expression systems for tunable production of heterologous proteins in Bacteroides thetaiotaomicron

Smith, Marshall B.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : Universtiy of Lethbridge, Department of Biological SciencesArts and ScienceDepartment of Biological Sciences, 2018)

Genetically engineering symbiotic bacteria remains an underexploited opportunity to improve host-health and create new classes of biological devices, such as diagnostics or intestinal delivery systems for therapeutics. ...
A genome-wide association study to identify diagnostic markers for human pathogenic Campylobacter jejuni strains

Buchanan, Cody J.; Webb, Andrew L.; Mutschall, Steven K.; Kruczkiewicz, Peter; Barker, Dillon Oliver Reese; Hetman, Benjamin M.; Gannon, Victor P. J.; Abbott, D. Wade; Thomas, James E.; Inglis, G. Douglas; Taboada, Eduardo N. (Frontiers MediaArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeNational Microbiology Laboratory at LethbridgeLethbridge Research and Development Centre, 2017)

Campylobacter jejuni is a leading human enteric pathogen worldwide and despite an improved understanding of its biology, ecology, and epidemiology, limited tools exist for identifying strains that are likely to cause ...
Glycomic analysis of the in vitro modification and utilization of chicken intestinal mucin O-glycan carbohydrates by the enteric poultry pathogen Clostridium perfringens

MacMillan, Jaclyn L.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : Universtiy of Lethbridge, Department of Biological SciencesArts and ScienceDepartment of Biological Sciences, 2019)

Clostridium perfringens is the etiological agent of necrotic enteritis (NE) in poultry. NE occurs within the small intestine and is characterized by intestinal mucus depletion and tissue inflammation. This disease costs ...
Heterologous expression and secretion of nanobodies targeting Campylobacter jejuni for intestinal health applications

McLean, Richard; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta : University of Lethbridge, Dept. of Chemistry and BiochemistryArts and ScienceDepartment of Chemistry and Biochemistry, 2016)

As strategies for engineering the enteric microflora continue to advance, the vision of a future with a secondary, artificial immune system increasingly comes into focus. There are numerous challenges that will need to be ...
Investigation of the structure and digestibility of fluorescently labeled carbohydrates using glycoside hydrolases

Anele, Anuoluwapo; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta : University of Lethbridge, Dept. of Biological SciencesArts and ScienceDepartment of Biological Sciences, 2016)

Developing alternatives to the use of antimicrobials is essential to maintaining the sustainability of animal production and lowering the prevalence of antimicrobial resistance. Prebiotics have not been readily adopted due ...
Production and secretion of heterologous immunomodulators in bacteroides thetaiotaomicron

Tingley, Jeffrey; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Dept. of Biological SciencesArts and ScienceDepartment of Biological Sciences, 2019)

Chronic and acute inflammation in the colon significantly impact human and animal health, and productivity in agriculture. Unfortunately, current treatments are not very effective for long-term management and treatment is ...
Understanding the recognition and utilization of homogalacturonan by Bacteroides thetaiotaomicron

Farnell, Benjamin J. (Lethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and BiochemistryArts and ScienceDepartment of Chemistry and Biochemistry, 2014)

Homogalacturonan (HG) is a structural plant cell wall polysaccharide and a key source of dietary fiber. The human genome does not contain a single enzyme known to be involved in pectin digestion, and therefore, in order ...

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