2026-09-19T03:46:33.768253500Zhttps://opus.uleth.ca/server/oai/requestoai:opus.uleth.ca:10133/852015-11-05T16:42:54Zcom_10133_3346com_10133_1com_10133_296col_10133_3347col_10133_298
ULethbridge OPUS Repository
supervisor
Whishaw, Ian Q.
author
Coles, Brenda Louise Kay
author
University of Lethbridge. Faculty of Arts and Science
2007-04-20T21:54:52Z
2007-04-20T21:54:52Z
1996
https://hdl.handle.net/10133/85
Neural changes in the forelimb cortex were studied at Postnatal (P) 10, 15, 20, 25, 30, and 100 days. Six biological markers of brain development, cortical thickness, Layer III pyramidal cell morphology, glial fibrillary acidic protein (GFAP), myelination, c-fos activity and Acetylcholinesterase (AChE) were correlated with the behavioural development of reaching, bimanual coordination, postural adjustment, and defensive feeding behaviours. The behaviours were filmed from P15 until P30 and then also in adulthood. For the behaviours there was a gradual development of the skilled patterns of paw and digit use seen in adults as well as in the patterns of movements in postural adjustment, carry behaviours and dodging and robbing type behaviours. The development of the adult patterns of movement were correlated to the morphological and biochemical changes in the cortex. The results suggest that the maturation of skilled movements depends upon anatomical and neurochemical maturation of the neocortex as well as upon learning.
en_US
Prefrontal cortex
Developmental psychology
Rodents -- Physiology
Rats as laboratory animals
Dissertations, Academic
Neural changes in forelimb cortex and behavioural development
Thesis
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