2026-09-20T19:03:15.231541400Zhttps://opus.uleth.ca/server/oai/request

oai:opus.uleth.ca:10133/7272019-02-08T06:10:15Zcom_10133_3346com_10133_1com_10133_296col_10133_3347col_10133_298

Sutherland, Robert J. Melvin, Neal University of Lethbridge. Faculty of Arts and Science 2009-07-07T20:51:40Z 2009-07-07T20:51:40Z 2008 https://hdl.handle.net/10133/727 xvi, 125 leaves : ill. ; 29 cm. -- Adult neurogenesis is a fundamental feature of mammalian nervous systems. Curiously, neurogenesis in the dentate gyrus is typically regarded as homogenous. This thesis challenges that view, and reports the discovery and characterization of a novel region of the dentate gyrus that consistently lacks basal neurogenesis. We demonstrate that this area, referred to as the neurogenically quiescent zone, represents approximately 1.5% of the total volume of the dentate gyrus, and that its location is invariant among animals. This region contains several critical cell types and molecular factors that are known to be critical to the neurogenic niche, including stem cells. We also present data that attempt to conceptualize the existence of this region in the context of early agerelated declines in neurogenesis. Finally, we demonstrate that, under some behavioural conditions, neurogenesis can be induced in this region, suggesting that, under basal conditions, it may simply lack the presence of pro-neurogenic factors. en_US Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008 Arts and Science Neuroscience Thesis (University of Lethbridge. Faculty of Arts and Science) Dissertations, Academic Developmental neurobiology Dentate gyrus Brain -- Research Rats as laboratory animals Hippocampus (Brain) Differential neurogenesis in the adult rat dentate gyrus Thesis Doctor of Philosophy Neuroscience Arts and Science Sciences University of Lethbridge ALU open.access