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Prusky, Glen McGill, Trevor University of Lethbridge. Faculty of Arts and Science 2009-07-07T20:51:15Z 2009-07-07T20:51:15Z 2008 https://hdl.handle.net/10133/726 xvii, 205 leaves : ill. ; 29 cm. -- The established model used for evaluating potential therapies for retinal disease has significant limitations. A new model is proposed to account for these limitations: the visual adaptation model. The visual adaptation model was developed to provide a novel approach for testing potential treatments for retinal disease, and the work in this thesis provides empirical support for this model. Specifically, we evaluated two potential therapies for retinal degenerative disease and examined their effects on vision and retinal anatomy. In addition, the profile of retinal reorganization and its functional correlates were examined in RCS rats and transgenic rats which express a rhodopsin mutation; however, immunohistological work targeted one specific line (S334ter-4). Collectively, these studies provide evidence that supports the retinal adaptation model. These studies also provide a novel view of retinal and visual function in retinal disease which should be considered when evaluating treatments involving retinal degeneration. en_US Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008 Arts and Science Neuroscience Thesis (University of Lethbridge. Faculty of Arts and Science) Dissertations, Academic Retina -- Diseases -- Research Retinal degeneration -- Research Retinitis pigmentosa -- Research Functionally non-adaptive retinal plasticity in rat models of human retinal degenerative disease Thesis Doctor of Philosophy Neuroscience Arts and Science Sciences University of Lethbridge ALU open.access