2026-09-19T04:09:48.109293800Zhttps://opus.uleth.ca/server/oai/requestoai:opus.uleth.ca:10133/7252019-03-07T06:05:14Zcom_10133_3346com_10133_1com_10133_296col_10133_3347col_10133_298
ULethbridge OPUS Repository
supervisor
Sutherland, Robert J.
supervisor
Metz, Gerlinde A. S.
author
Faraji, Jamshid
author
University of Lethbridge. Faculty of Arts and Science
2009-07-07T20:50:44Z
2009-07-07T20:50:44Z
2008
https://hdl.handle.net/10133/725
Stress-related cognitive changes are still a matter of debate. In some
particular neuropathological conditions such as focal ischemia, cognitive
functions have been shown to be significantly impaired. These conditions,
however, may be improved by some factors such as steroid hormones. The
purpose of the current thesis was to assess the structural and functional effects
of corticosterone-related experiences on the hippocampus before and after
endothelin-1 (ET-1)-induced stroke. We found corticosterone-related experiences
enhance the hippocampal recovery, and improve its function in both wet and dryland
tasks after ET-1-induced focal stroke. Structural and functional effects of
such experiences prior to the focal ischemia in the hippocampus, however,
showed that stress, not corticosterone is a strong inhibitor for hippocampal
recovery.
en_US
Dissertations, Academic
Cerebrovascular disease -- Research
Cerebrovascular disease -- Animal models
Spatial behavior in animals -- Research
Brain -- Research
Hippocampus (Brain) -- Physiology
Rats as laboratory animals
Stress (Physiology) -- Research
Rats -- Effect of stress on
Structural alterations in the hippocampus and spatial behavior by stress in male and female rats : protections, and recovery in water-based and dry-land tasks
Thesis
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URL
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application/pdf
FARAJI_JAMSHID_PHD_2008.pdf
URL
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text/plain
FARAJI_JAMSHID_PHD_2008.pdf.txt