2026-09-21T03:11:40.056543400Zhttps://opus.uleth.ca/server/oai/request

oai:opus.uleth.ca:10133/66032023-10-19T16:24:52Zcom_10133_3346com_10133_1com_10133_296col_10133_3347col_10133_298

Whishaw, Ian Q. Mohajerani, Majid H. Mirza Agha, Behroo University of Lethbridge. Faculty of Arts and Science 2023-10-13T16:28:40Z 2023-10-13T16:28:40Z 2023 https://hdl.handle.net/10133/6603 This thesis investigates the stability of points on the motor cortex of the mouse produced using optogenetic stimulation. Mice were implanted with fiber optic probes in four areas of the motor cortex and one in a non-motor area for control. They received stimulation of various frequency and duration as they engaged in six different voluntary and automatic behaviour. Control stimulation was also administered via a separate optic probe located on the side of the apparatus. The general findings are that the outcome of the stimulation depends on the ongoing behaviour of the mouse at the time of stimulation. Thus, stimulation effects are unstable, and behaviour is a contributing factor. en Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience Arts and Science Department of Neuroscience Thesis (University of Lethbridge. Faculty of Arts and Science) stability of points motor cortex optogenetic stimulation behavioural influences Motor cortex--Research Brain stimulation--Research Mice as laboratory animals Mice--Behavior Movement sequences--Research Optogenetics Neurosciences Dissertations, Academic Behavioural influences on the stability of points with optogenetic stimulation of motor cortices Thesis Ph.D 0317 Yes open.access