2026-09-19T06:37:20.529823400Zhttps://opus.uleth.ca/server/oai/requestoai:opus.uleth.ca:10133/63872022-12-03T07:04:26Zcom_10133_3346com_10133_1com_10133_296col_10133_3347col_10133_298
ULethbridge OPUS Repository
supervisor
Sutherland, Robert J.
supervisor
Mohajerani, Majid H.
author
Lacoursiere, Sean
author
University of Lethbridge. Faculty of Arts and Science
2022-12-02T18:49:17Z
2022-12-02T18:49:17Z
2022
https://hdl.handle.net/10133/6387
Alzheimer’s disease (AD) is characterized by the prion-like propagation of misfolded proteins that appears dependent on the initial accumulation of amyloid-β (Aβ). But the role of Aβ in cognitive impairment is still unclear. To determine the causal role of Aβ in AD, mouse models expressing pathological features of AD were intracerebrally seeded with Aβ. Behavioural and immunohistochemical techniques were used to assess the effects of seeding. Seeding was found to increase Aβ plaque deposition and microgliosis throughout the brain after a brief inoculation period. The effect was dependent on the presence of specific knocked-in genes. Seeding was also found to increase the presence of tau hyperphosphorylation in isolated parts of the brain. Yet, no significant correlation between pathology and memory was found. In summary, large increases in Aβ plaque and microgliosis do not initially cause cognitive impairment. Suggesting other underlying disease processes may be driving cognitive decline in AD.
en_CA
Neuroscience
Alzheimer's
Seeding
Molecular
Behavioural
An exploration of amyloid-β seeding in mouse models of dementia
Thesis
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URL
http://localhost:4000/bitstreams/f9434e57-4b67-491d-af6f-effc7fe7121d/download
File
MD5
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application/pdf
LACOURSIERE_SEAN-PHD_2022.pdf
URL
http://localhost:4000/bitstreams/7b9ebb86-3802-4546-8b16-353c3d0aa453/download
File
MD5
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text/plain
LACOURSIERE_SEAN-PHD_2022.pdf.txt