2026-09-21T06:13:24.766821600Zhttps://opus.uleth.ca/server/oai/requestoai:opus.uleth.ca:10133/54232019-06-21T06:04:58Zcom_10133_3346com_10133_1com_10133_296col_10133_3347col_10133_298
ULethbridge OPUS Repository
supervisor
Sutherland, Robert J.
supervisor
McDonald, Robert J.
author
Gidyk, Darryl C.
author
University of Lethbridge. Faculty of Arts and Science
2019-06-20T17:16:53Z
2019-06-20T17:16:53Z
2019
https://hdl.handle.net/10133/5423
We examine the maintenance and behavioural expression of long-term memories acquired in the absence of the hippocampus. The hypothesis that the hippocampus is necessary to form stable and detailed long-term memories is tested. We find rats with extensive hippocampal damage made before learning exhibit normal maintenance and behavioural expression of contextual fear memory, object discrimination, and context discrimination. The discovery that non-hippocampal networks can encode, maintain, and retrieve memories, widely-thought to be dependent on the hippocampus and its consolidation processes adds to a growing body of literature which draws into question most views of the hippocampus and memory consolidation. Our findings suggest: 1) hippocampal-dependent systems-level consolidation is not required for stable long-term memory in the rat; 2) non-hippocampal networks possess sufficient representational complexity to support normal discriminative memory-guided behaviours; 3) the broad distinction between hippocampal and non-hippocampal memories requires re-evaluation through rigorous experimentation, rather than adherence to modal views.
en_US
Hippocampus (Brain)
Long-term memory
Maintenance and Behavioural Expression of Long-term Memories Acquired in the Absence of the Hippocampus
Thesis
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URL
http://localhost:4000/bitstreams/6474cc44-8792-4e05-afb5-a6e1b846a312/download
File
MD5
5bffe07e7e2a279aa421990ab57223c2
2468429
application/pdf
Gidyk_Darryl_PhD_2019.pdf
URL
http://localhost:4000/bitstreams/94747bc2-ef87-4d2b-8655-aadeb5a499f9/download
File
MD5
8d9fd291ff2fb2a3422fca2f072c24ce
222338
text/plain
Gidyk_Darryl_PhD_2019.pdf.txt