2026-09-19T18:46:09.843215300Zhttps://opus.uleth.ca/server/oai/requestoai:opus.uleth.ca:10133/54022019-06-20T17:10:16Zcom_10133_3346com_10133_1com_10133_296col_10133_3347col_10133_298
ULethbridge OPUS Repository
supervisor
Sutherland, Robert J.
supervisor
McDonald, Robert J.
author
Lee, Justin Quinn
author
University of Lethbridge. Faculty of Arts and Science
2019-06-19T15:17:36Z
2019-06-19T15:17:36Z
2019
https://hdl.handle.net/10133/5402
Contemporary views on the organization of long-term memory (LTM) suggest the hippocampus is involved in a unique category of LTM. Recent experiments illustrate that hippocampal damage before and after a learning episode result in different patterns of amnesia, and many types of memory are affected by damage after the learning episode. These results challenge contemporary views of LTM organization, and motivate the present thesis. We describe a concept, termed heterarchic reinstatement (HR) to account for the pattern of amnesia following hippocampal damage. We observed a pattern of results, in both hippocampal activity and amnesia following damage that support the HR view. However, an experiment using temporary inactivation reveals limitations of the HR view. Thus, we provide a new predictive model of hippocampus and memory, termed the Memory Manifold Theory (MMT), that incorporates the HR concept and our observations along with the broader research literature.
en_US
Hippocampus
Rat
Memory
Patterns of hippocampal amnesia and population activity in rats: Implications for categorical and single-process models of long-term memory organization
Thesis
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URL
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MD5
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application/pdf
LEE_JUSTIN_PHD_2019.pdf
URL
http://localhost:4000/bitstreams/c873e63f-7a01-4647-a58c-dbcf972f1777/download
File
MD5
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text/plain
LEE_JUSTIN_PHD_2019.pdf.txt