2026-09-21T22:31:26.068862900Zhttps://opus.uleth.ca/server/oai/requestoai:opus.uleth.ca:10133/52672019-01-15T06:05:01Zcom_10133_3346com_10133_1com_10133_296col_10133_3347col_10133_298
ULethbridge OPUS Repository
supervisor
Mohajerani, Majid H.
supervisor
Whishaw, Ian Q.
author
Mirza Agha, Behroo
author
University of Lethbridge. Faculty of Arts and Science
2019-01-14T18:48:15Z
2019-01-14T18:48:15Z
2018
https://hdl.handle.net/10133/5267
The current thesis investigated the role of acetylcholine in recovery from diaschisis and skilled hand movement following ischemic stroke in a mouse model of photothrombotic stroke. Mice were trained in skilled reaching task in which they were taught to use their hand to reach for, grasp, and eat a food pellet. They were implanted with a fiber optic in their nucleus basalis, the main source of cholinergic projections to the sensorimotor cortex, for optogenetic stimulation and an electrode in their motor cortex for local field potential recordings. Then they received photothrombotic stroke in their primary forelimb somatosensory cortex. The general findings are that upregulation of acetylcholine reduced diaschisis following photothrombotic stroke to primary forelimb somatosensory area as measured by endpoint scores. However, upregulation of acetylcholine did not improve skilled hand movements as measured by movement component scores and fictive eating analysis.
en_US
Acetylcholine -- Physiological effect
Cerebral ischemia -- Animal models -- Research
Neuroplasticity -- Research
Cerebrovascular disease -- Research
Sensorimotor cortex -- Research
acetylcholine
brain plasticity
hand movements
ischemic stroke
photothrombotic stroke
somatosensory forelimb area
Probing the impact of cholinergic circuits in functional recovery after focal cerebral ischemia
Thesis
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URL
http://localhost:4000/bitstreams/1ccba15d-b736-444b-a09f-30fa21d147f3/download
File
MD5
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application/pdf
MIRZA_AGHA_BEHROO_MSC_2018.pdf
URL
http://localhost:4000/bitstreams/6c562604-d8f2-466b-bbe2-698039c0ac1b/download
File
MD5
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text/plain
MIRZA_AGHA_BEHROO_MSC_2018.pdf.txt