2026-09-18T21:49:52.689269100Zhttps://opus.uleth.ca/server/oai/requestoai:opus.uleth.ca:10133/47932017-03-10T20:56:35Zcom_10133_3346com_10133_1com_10133_296col_10133_3347col_10133_298
ULethbridge OPUS Repository
supervisor
Pyle, Gregory
author
Heerema, Jody L.
author
University of Lethbridge. Faculty of Arts and Science
2017-03-10T20:56:35Z
2017-03-10T20:56:35Z
2017
https://hdl.handle.net/10133/4793
Endocrine disrupting compounds (EDCs) are persistent in wastewater effluent and discharged into receiving waters. Some EDCs can interact with the thyroid system in vertebrates. The present study investigated the effects of TH disruption on olfactory responses in Lithobates (Rana) catesbeiana tadpoles. A neurophysiological and a behavioural technique were developed to study olfactory acuity in tadpoles. To investigate the effects of thyroid hormone (TH) disruption, tadpoles were exposed to either 3,5’,3-triiodothyronine (T3), thyroxine (T4), 17β-estradiol (E2), known EDCs, or wastewater effluent. Olfactory-mediated avoidance responses to a chemosensory stimulus were measured. Exposure to T3 and treated wastewater resulted in impaired avoidance responses. Exposures to T4, E2 and known EDCs had no effect on behavioural responses. These results indicated that EDCs in wastewater effluent may contribute to olfactory impairment through TH disruption. Chemosensory-mediated behaviour may serve as an environmentally relevant endpoint to determine possible effects of TH disruption in wastewater effluent receiving waters.
en_US
chemosensory-mediated behaviour
endocrine disrupting compounds
olfactory acuity
premetamorphic tadpoles
thyroid hormone disruption
wastewater effluent
Effects of thyroid hormones, thyroid hormone disruptors, and treated wastewater on bullfrog tadpole chemosensory function and behaviour
Thesis
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URL
http://localhost:4000/bitstreams/c09527cc-21c9-44d6-b46d-cafae69de82c/download
File
MD5
cdb5ec302bfdb81d08bfa1a25cac5aaa
1193684
application/pdf
HEEREMA_JODY_MSC_2017.pdf
URL
http://localhost:4000/bitstreams/70685a05-ec24-42b6-bd48-7066dee1179e/download
File
MD5
630b91d32db6a65cf7f250003107ef0d
199940
text/plain
HEEREMA_JODY_MSC_2017.pdf.txt