2026-09-19T15:26:39.819421200Zhttps://opus.uleth.ca/server/oai/requestoai:opus.uleth.ca:10133/32542019-02-07T06:09:42Zcom_10133_3346com_10133_1com_10133_296col_10133_3347col_10133_298
ULethbridge OPUS Repository
supervisor
Cross, Albert
author
McCreary, J. Keiko
2013-05-14T22:44:15Z
2013-05-14T22:44:15Z
2012
https://hdl.handle.net/10133/3254
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) has proven itself to be a beneficial technique in the field of Neuroscience. This thesis applies MEMRI to studies in neuroscience by first establishing the limitations concerning the use of MEMRI in live rats. Experiment 1 used an osmotic pump for manganese (Mn) delivery to the lateral ventricles for acquisition of anatomical images using MEMRI. From my knowledge, this was the first method demonstrating slow infusion of Mn to the lateral ventricles. In Experiment 2, MEMRI was used for volumetric analysis the whole brain and hippocampus of prenatally stressed rats. To my knowledge, this study was the first to investigate the effect of generational prenatal stress on the structure of a rat’s brain using MEMRI and histology. Additionally, Experiment 2 investigated the use of a subcutaneous osmotic pump to deliver Mn for MEMRI. A summary on the use of MEMRI in Neuroscience concludes this thesis, with a discussion on the methods used and related technical considerations.
en_US
Brain -- Magnetic resonance imaging
Rats -- Effect of stress on
Magnetic resonance imaging
Neurosciences
Dissertations, Academic
Applications of manganese-enhanced magnetic resonance imaging in neuroscience
Thesis
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URL
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File
MD5
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application/pdf
MCCREARY_KEIKO_MSC_2012.pdf
URL
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MCCREARY_KEIKO_MSC_2012.pdf.txt