2026-09-18T19:59:51.683799600Zhttps://opus.uleth.ca/server/oai/request

oai:opus.uleth.ca:10133/25872019-04-04T20:39:45Zcom_10133_3346com_10133_1com_10133_296col_10133_3347col_10133_298

Sutherland, Robert J. Spanswick, Simon C. University of Lethbridge. Faculty of Arts and Science 2011-12-22T22:28:09Z 2011-12-22T22:28:09Z 2010 https://hdl.handle.net/10133/2587 xii, 191 leaves : ill. (chiefly col.) ; 28 cm Long-term adrenalectomy (ADX) results in a specific loss of dentate gyrus granule cells in the hippocampus of adult rats, occurring over a period of weeks to months. This loss of granule cells results in cognitive deficits in a number of tasks that depend on intact hippocampal function. The gradual nature of ADX-induced cell death and the ensuing deficits in cognition are similar to those experienced by patient populations suffering from a variety of pathological conditions. Here we present an animal model by which we use ADX to produce a loss of granule cells within the hippocampus of rats. We also provide experimental evidence for a treatment strategy by which the lost granule cells may be replaced, with the goal of functional recovery in mind. en_US Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2010 Arts and Science Department of Neuroscience Thesis (University of Lethbridge. Faculty of Arts and Science) Dentate gyrus -- Research Hippocampus (Brain) -- Research Adrenalectomy Developmental neurobiology Brain -- Research Rats as laboratory animals Neuroplasticity -- Research Dissertations, Academic Adrenalectomy-induced neuronal degeneration : development of a novel animal model of cognitive dysfuntion and neurogenic treatment strategies Thesis Doctor of Philosophy PhD Neuroscience Arts and Sciences University of Lethbridge ALU open.access