2026-09-19T11:28:39.535789200Zhttps://opus.uleth.ca/server/oai/requestoai:opus.uleth.ca:10133/25182019-02-07T06:05:42Zcom_10133_3346com_10133_1com_10133_296col_10133_3347col_10133_298
ULethbridge OPUS Repository
supervisor
Prusky, Glen
author
Rakai, Brooke D.
author
University of Lethbridge. Faculty of Arts and Science
2011-08-19T19:22:04Z
2011-08-19T19:22:04Z
2008
https://hdl.handle.net/10133/2518
Stroke outcome is highly variable. Experiments in this thesis test the hypothesis that experience prior to a stroke is an important variable in the manifestation of stroke. Optokinetic tracking was used to evaluate the effects of visual cortex stroke and MCA occlusion in rats. Normal laboratory rats showed a small, but significant decrease in tracking thresholds following visual cortex stroke. Animals with developmental visuomotor experience or reach training experience in adulthood, however, had tracking thresholds which were substantially increased, and the effects of visual cortex strokes were greater. MCA occlusions did not affect tracking behaviour. These data indicate that specific experiences engage neural plasticity that can alter brain function. These changes can, in turn, affect the behavioural manifestation of a stroke. Understanding the effect that environmental experience has on stroke outcome promises to enable better characterization of strokes, and set appropriate behavioural baselines for the measurement of recovery of function.
en_US
Cerebrovascular disease
Cerebrovascular disease -- Animal models
Cerebrovascular disease -- Research
Neuroplasticity
Neuroplasticity -- Research
Neuroplasticity -- Animal models
Rats as laboratory animals
Dissertations, Academic
Experience dependent plasticity of stroke outcome
Thesis
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URL
http://localhost:4000/bitstreams/ef3fe7df-2d85-4743-8991-09708eecb5a4/download
File
MD5
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application/pdf
RAKAI_BROOKE_MSC_2008.pdf
URL
http://localhost:4000/bitstreams/2763608c-e430-40ce-875d-760a9584e20a/download
File
MD5
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text/plain
RAKAI_BROOKE_MSC_2008.pdf.txt