2026-09-19T15:01:33.958239800Zhttps://opus.uleth.ca/server/oai/requestoai:opus.uleth.ca:10133/1162015-11-17T18:44:04Zcom_10133_3346com_10133_1com_10133_560com_10133_442com_10133_296col_10133_3347col_10133_561col_10133_298
ULethbridge OPUS Repository
supervisor
Kolb, Bryan
author
Gibb, Robbin L.
author
University of Lethbridge. Faculty of Arts and Science
2007-04-24T21:27:20Z
2007-04-24T21:27:20Z
2001
https://hdl.handle.net/10133/116
The current work explores the therapeutic potential of experiential treatments for enhancing functional recovery and anatomical change after early brain damage. Normal rats and rats with perinatal cortical lesions (P2 or P7) were exposed to one of the following treatments: complex housing as juveniles, complex housing as adults, prenatal tactile stimulation, postnatal tactile stimulation, or postnatal handling (removal from the nest with no additional stimulaion). Behavior was assessed in adulthood the Morris water task and the Whishaw reaching task. There were sex differences in the details of the effect of experience on both behavioral recovery and brain morphology. For both sexes treatments initiated prior to or immediately after brain injury were most effective in improving functional outcome. This was correlated with changes in dendritic arborization and Acetylcholinesterase staining. The results suggest that behavioral treatments can be used to stimulate functional recovery after early brain injury.
en_US
Brain damage -- Treatment
Brain damage -- Animal models
Dissertations, Academic
Experimental stimulation as a treatment for early brain damage
Thesis
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
URL
http://localhost:4000/bitstreams/a27c6ece-8cc3-4e14-a37d-e1dcddbad34d/download
File
MD5
a323c99386fcf7668cd6675fe1a34adf
5104087
application/pdf
MQ61039.pdf
URL
http://localhost:4000/bitstreams/43dae846-96ba-4fef-b0e8-2319c3030f1a/download
File
MD5
4dc521a560f86db8acb73db18edfad2c
271641
text/plain
MQ61039.pdf.txt