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dc.contributor.supervisor Kovalchuk, Olga
dc.contributor.author Tamminga, Jan
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2009-07-08T20:49:32Z
dc.date.available 2009-07-08T20:49:32Z
dc.date.issued 2008
dc.identifier.uri https://hdl.handle.net/10133/746
dc.description xii, 121 leaves : ill. ; 29 cm. en
dc.description.abstract Approximately 45% of men will develop cancer during their lifetime; some of which will be of reproductive age (Canadian Cancer Society, 2008). Current advances in treatment regimens such as radiotherapy have significantly lowered cancer-related mortality rates; however, one major quality-of-life issue in cancer survivors is the ability to produce healthy offspring. Exposure to ionizing radiation (IR) leads to genomic instability in the germline, and further to transgeneration genome instability in unexposed offspring of preconceptionally exposed parents. The results presented in this thesis define, in part, the molecular consequences of direct and indirect irradiation for the male germline. Direct exposure results in a significant accumulation of DNA damage, altered levels of global DNA methylation and microRNAome dysregulation of testis tissue. Localized cranial irradiation results in a significant accumulation of unrepaired DNA lesions and loss of global DNA methylation in the rodent (rat) germline. Biological consequences of the changes observed are discussed. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Radiation carcinogenesis -- Animal models en
dc.subject Radiation carcinogenesis en
dc.subject DNA -- Effect of radiation on en
dc.subject Cancer -- Radiography -- Complications -- Research en
dc.subject Germ cells -- Effect of radiation on en
dc.title Radiation-induced epigenome deregulation in the male germline en
dc.type Thesis en
dc.publisher.faculty Arts and Science en
dc.publisher.department Biological Sciences en
dc.degree.level Masters


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