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dc.contributor.supervisor Zovoilis, Athanasios
dc.contributor.supervisor Patel, Trushar R.
dc.contributor.author Cheng, Yubo
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2021-11-23T21:45:39Z
dc.date.available 2021-11-23T21:45:39Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/10133/6096
dc.description.abstract Despite recent advances in our understanding of gene expression networks in Alzheimer's disease (AD), the molecular mechanisms of its pathogenesis still remain unclear. Previous studies have shown that mechanisms involving non protein-coding RNAs transcribed by Short Interspersed Nuclear Element (SINE) are key in maintaining transcriptional homeostasis in cells. RNAs from SINE B2 repeats in mouse and SINE Alu repeats in human, control gene expressions through binding and inhibition of RNA Polymerase II. Here, an integrative RNA genomics and bioinformatics approach is applied to investigate the connection between SINE RNAs, amyloid beta neuro-toxicity and dementia both in mouse models of AD and brains of AD patients. Our data shows that processing of SINE RNAs is abnormally increased in response to amyloid beta toxicity, and is connected with deregulation of gene expression during amyloid beta pathology and AD. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistry en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject non-coding RNA en_US
dc.subject Alzheimer's disease en_US
dc.subject SINE RNAs en_US
dc.subject amyloid beta neuro-toxicity en_US
dc.subject gene expression deregulation en_US
dc.subject Non-coding RNA -- Research en_US
dc.subject Alzheimer's disease -- Research en_US
dc.subject Amyloid beta-protein en_US
dc.subject Transposons -- Research en_US
dc.subject Mobile genetic elements en_US
dc.subject Genetic transcription -- Regulation en_US
dc.subject Dissertations, Academic en_US
dc.title Elucidating the role of SINE non-coding RNAs in amyloid beta pathology en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Chemistry and Biochemistry en_US
dc.degree.level Ph.D en_US
dc.proquest.subject 0715 en_US
dc.proquest.subject 0369 en_US
dc.proquestyes Yes en_US


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