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dc.contributor.supervisor Kovalchuk, Igor
dc.contributor.supervisor Kovalchuk, Olga
dc.contributor.author Zaiachuk, Mariia
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2021-10-28T15:56:55Z
dc.date.available 2021-10-28T15:56:55Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/10133/6081
dc.description.abstract Inflammation is the immune system’s response to an injury due to any agent. Currently, there is a wide array of anti-inflammatory agents available; however, they cause numerous side effects which compromise patients’ quality of life. Therefore, new antiinflammatory agents and strategies are required. Multiple research articles have demonstrated the strong potential of Cannabis sativa extracts and their active ingredients, including cannabinoids and terpenes, to be used in the treatment of inflammatory disorders. The current study explores the immunomodulatory potential of cannabis extracts in vitro. We investigated how the extracts of selected novel cannabis cultivars influence the secretion of cytokines in lipopolysaccharide (LPS)-induced macrophages. We discovered that studied cannabis extracts significantly reduced the levels of cytokines, such as IL-1β, TNF-α, IL-6, IL-8, MCP-1, and IL-10, while not being cytotoxic to macrophages. This study may serve as a roadmap for the future analysis of the anti-inflammatory effects of medical cannabis in vivo. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject immunomodulators en_US
dc.subject macrophages en_US
dc.subject cytokines en_US
dc.subject Cannabis sativa extracts en_US
dc.subject anti-inflammatory agents en_US
dc.subject inflammatory disorder treatments en_US
dc.subject Anti-inflammatory agents -- Research en_US
dc.subject Cannabis -- Therapeutic use -- Research en_US
dc.subject Plant extracts -- Therapeutic use -- Research en_US
dc.subject Botany, Medical en_US
dc.subject Medicinal plants -- Research en_US
dc.subject Materia medica, Vegetable en_US
dc.subject Cannabinoids -- Therapeutic use -- Research en_US
dc.subject Terpines -- Therapeutic use -- Research en_US
dc.subject Cytokines -- Research en_US
dc.subject Macrophages -- Research en_US
dc.subject Biological response modifiers en_US
dc.subject Immune response -- Regulation en_US
dc.subject Dissertations, Academic en_US
dc.title The effects of Cannabis sativa extracts on human macrophages in vitro en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US
dc.degree.level Masters en_US
dc.proquest.subject 0982 en_US
dc.proquest.subject 0307 en_US
dc.proquest.subject 0308 en_US
dc.proquestyes Yes en_US


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