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dc.contributor.author Lopez, Priscilla
dc.contributor.author Lara, Humberto H.
dc.contributor.author Mullins, Sean M.
dc.contributor.author Black, David M.
dc.contributor.author Ramsower, Heidi M.
dc.contributor.author Alvarez, Marcos M.
dc.contributor.author Williams, Tayler L.
dc.contributor.author Lopez-Lozano, Xochitl
dc.contributor.author Weissker, Hans-Christian
dc.contributor.author Garcia, A. Patricio
dc.contributor.author Garzon, Ignacio L.
dc.contributor.author Demeler, Borries
dc.contributor.author Lopez-Ribot, Jose Luis
dc.contributor.author Yacaman, Miguel J.
dc.contributor.author Whetten, Robert L.
dc.date.accessioned 2021-09-23T19:35:12Z
dc.date.available 2021-09-23T19:35:12Z
dc.date.issued 2018
dc.identifier.citation Lopez, P., Humberto, H., Mullins, S. M., Black, D. A., Ramsower, H. M., Alvarez, M. M., Williams, T. L., Lopez-Lozano, X., Weissker, H.-C., Garcia, A. P., Garzon, I. L., Demeler, B., Lopez-Ribot, J. L., Yacaman, M. J., & Whetten, R. L. (2018). Tetrahedral (T) closed-shell cluster of 29 silver atoms & 12 lipoate ligands, [Ag29(R-a-LA)12](3-): Antibacterial and antifungal activity. ACS Applied Nano Materials, 1(4), 1595-1602. https://doi.org/10.1021/acsanm.8b00069 en_US
dc.identifier.uri https://hdl.handle.net/10133/6041
dc.description Accepted author manuscript en_US
dc.description.abstract Here we report on the identification and applications of an aqueous 29-atom silver cluster stabilized with 12 lipoate ligands, i.e. Ag29(R-α–LA)12 or (29,12), wherein R-α–LA = R-α-lipoic acid, a natural dithiolate. Its uniformity is checked by HPLC-ESI-MS and analytical ultracentrifugation, which confirms its small dimension (∼3 nm hydrodynamic diameter). For the first time, this cluster has been detected intact via electrospray ionization mass spectrometry, allowing one to confirm its composition, its [3-] charge-state, and the 8-electron shell configuration of its metallic silver core. Its electronic structure and bonding, including T-symmetry and profound chirality in the outer shell, have been analyzed by DFT quantum-chemical calculations, starting from the known structure of a nonaqueous homologue. The cluster is effective against Methicillin-Resistant Staphylococcus aureus bacteria (MRSA) at a minimum inhibitory concentration (MIC) of 0.6 mg-Ag/mL. A preformed Candida albicans fungal biofilm, impermeable to other antifungal agents, was also inhibited by aqueous solutions of this cluster, in a dose–response manner, with a half-maximal inhibitory concentration (IC50) of 0.94 mg-Ag/mL. Scanning electron micrographs showed the post-treatment ultrastructural changes on both MRSA and C. albicans that are characteristic of those displayed after treatment by larger silver nanoparticles. en_US
dc.language.iso en_US en_US
dc.publisher American Chemical Society en_US
dc.subject Silver clusters en_US
dc.subject Lipoic acid en_US
dc.subject Antibiotic en_US
dc.subject Analytical ultracentrifuge en_US
dc.subject Electrospray ionization mass spectroscopy en_US
dc.subject Ag29 en_US
dc.title Tetrahedral (T) closed-shell cluster of 29 silver atoms & 12 lipoate ligands, [Ag29(R-a-LA)12](3-): antibacterial and antifungal activity en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Chemistry and Biochemistry en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Texas en_US
dc.publisher.institution University of Texas Health Science Center at San Antonio en_US
dc.publisher.institution Aix Marseille University en_US
dc.publisher.institution Universidad Nacional Autonoma de Mexico en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.url https://doi.org/10.1021/acsanm.8b00069 en_US


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