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dc.contributor.supervisor Pyle, Gregory
dc.contributor.author Razmara, Parastoo
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2021-05-28T20:39:26Z
dc.date.available 2021-05-28T20:39:26Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/10133/5897
dc.description.abstract Fish depend on olfaction for reproduction and survival. Here, using molecular to behavioural endpoints, we compared the effect of two neurotoxic contaminants, Cu ions (Cu2+) and copper nanoparticles (CuNPs) on rainbow trout olfaction. Exposure to equitoxic concentrations of Cu2+ and CuNPs resulted in distinct toxicity patterns over time in rainbow trout olfactory mucosa. During continuous exposure to Cu2+, fish olfactory function was partially recovered. However, the olfactory function of CuNP-exposed fish showed a steady decline over time. Gene-transcript profiles of Cu2+-exposed olfactory mucosa showed neural repair mechanisms were upregulated to recover the olfactory dysfunction. In the CuNP treatment, dysregulation of transcripts that regulate function and reestablishment of damaged olfactory mucosa represented key mechanisms of CuNP-induced olfactory toxicity. Moreover, our findings revealed the CuNP-induced olfactory dysfunction was irreversible after the 7-day recovery period. Collectively, CuNPs and Cu2+ exert their effects via separate mechanisms in rainbow trout olfactory mucosa. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject toxicology en_US
dc.subject copper nanoparticles en_US
dc.subject rainbow trout en_US
dc.subject olfactory sensory neurons en_US
dc.subject Copper -- Toxicology en_US
dc.subject Rainbow trout -- Sense organs -- Effect of heavy metals on en_US
dc.subject Nanoparticles -- Toxicology en_US
dc.subject Neurotoxic agents en_US
dc.subject Smell en_US
dc.subject Olfactory receptors en_US
dc.subject Dissertations, Academic en_US
dc.title Effect of copper nanoparticles on rainbow trout olfaction and recovery en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US
dc.degree.level Ph.D en_US
dc.proquest.subject 0383 en_US
dc.proquest.subject 0317 en_US
dc.proquest.subject 0306 en_US
dc.proquestyes Yes en_US


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