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dc.contributor.supervisor Kolb, Bryan
dc.contributor.supervisor Mohajerani, Majid H.
dc.contributor.author Hossain, Shakhawat
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2020-01-17T19:09:47Z
dc.date.available 2020-01-17T19:09:47Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10133/5667
dc.description.abstract Alzheimer’s Disease (AD) is a one of the largest health crises in the world. Noise stress is identified as one of the risk factors for AD development. A series of research demonstrates the adverse of effects of both pre- and post-natal auditory/noise stress on the brain development in adult offspring and adults APPNL-G-F mice, a mouse model of AD. There are limited but expensive pharmaceutical interventions to treat AD and most of the treatment options are not for cure or prevention, but to slow down the progression of the disease. The aim of this thesis was to examine the effect of tactile stimulation (TS) on AD-like symptoms and pathology. The results from this study suggest that TS improves the AD-like symptoms of cognition, motor, and anxiety-like behaviours, and that these improvements are associated with reduced AD pathology in APP mice. en_US
dc.description.sponsorship ARNET, NSERC en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Alzheimer’s disease en_US
dc.subject Neuroplasticity en_US
dc.subject Noise pollution en_US
dc.subject Stress (Physiology) en_US
dc.title Pre-clinical trials: the impact of tactile stimulation on the development of Alzheimer's Disease pathology in APP mice. en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters en_US
dc.proquest.subject Neurosciences [0317 en_US
dc.proquest.subject Mental health [0347] en_US
dc.proquest.subject Medicine [0564] en_US
dc.proquestyes Yes en_US


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