Browsing Faculty Research and Publications by Title

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  • Lehmann, Hugo; Sparks, Fraser T.; Spanswick, Simon C.; Hadikin, Crystal; McDonald, Robert J.; Sutherland, Robert J. (Cold Spring Harbor Laboratory PressArts and ScienceDepartment of NeuroscienceTrent UniversityUniversity of Lethbridge, 2009)
    We present evidence that certain learning parameters can make a memory, even a very recent one, become independent of the hippocampus. We confirm earlier findings that damage to the hippocampus causes severe retrograde ...
  • Gomez-Lopez, Nardhy; Tanaka, Satomi; Zaeem, Zoya; Metz, Gerlinde A. S.; Olson, David M. (Biomed Central LtdArts and ScienceDepartment of NeuroscienceUniversity of AlbertaUniversity of Lethbridge, 2013)
    Background: Parturition has been widely described as an immunological response; however, it is unknown how this is triggered. We hypothesized that an early event in parturition is an increased responsiveness of ...
  • Zucchi, Fabiola C. R.; Yao, Youli; Ward, Isaac D.; Ilnytskyy, Yaroslav; Olson, David M.; Benzies, Karen; Kovalchuk, Igor; Kovalchuk, Olga; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceDepartment of Biological SciencesUniversity of LethbridgeUniversity of Mato Grosso StateUniversity of AlbertaUniversity of Calgary, 2013)
    The gestational state is a period of particular vulnerability to diseases that affect maternal and fetal health. Stress during gestation may represent a powerful influence on maternal mental health and offspring brain ...
  • Christie, Gregory J.; Cook, Charles M.; Ward, Brian J.; Tata, Matthew S.; Sutherland, Janice; Sutherland, Robert J.; Saucier, Deborah M. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeSimon Fraser UniversityUniversity of Ontario Institute of Technology, 2013)
    This study investigated how both sex and individual differences in a mental rotation test (MRT) influence performance on working memory (WM). To identify the neural substrate supporting these differences, brain electrical ...
  • Gutierrez-Ibanez, Cristian I.; Iwaniuk, Andrew N.; Moore, Bret A.; Fernandez-Juricic, Esteban; Corfield, Jeremy R.; Krilow, Justin M.; Kolominsky, Jeffrey; Wylie, Douglas R. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of AlbertaUniversity of LethbridgePurdue University, 2014)
    Two main models have been proposed to explain how the relative size of neural structures varies through evolution. In the mosaic evolution model, individual brain structures vary in size independently of each other, whereas ...
  • Sacrey, Lori-Ann Rosalind; Clark, Callie Anne Marie; Whishaw, Ian Q. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2009)
    Parkinson’s disease (PD) results in movement and sensory impairments that can be reduced by familiar music. At present, it is unclear whether the beneficial effects of music are limited to lessening the bradykinesia of ...
  • Holec, Victoria; Pirot, Heather L.; Euston, David R. (Frontiers Research FoundationsArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2014)
    The rat anterior cingulate cortex (ACC) mediates effort-based decision making when the task requires the physical effort of climbing a ramp. Normal rats will readily climb a barrier leading to high reward whereas rats ...
  • Spanswick, Simon C.; Lehmann, Hugo; Sutherland, Robert J. (Hindawi PublishingArts and ScienceDepartment of NeuroscienceUniversity of CalgaryTrent UniversityUniversity of Lethbridge, 2011)
    Long-term adrenalectomy (ADX) results in an extensive and specific loss of dentate gyrus granule cells in the hippocampus of adult rats. This loss of granule cells extends over a period of weeks to months and ultimately ...
  • Spanswick, Simon C.; Sutherland, Robert J. (Cold Spring Harbor Laboratory PressArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2010)
    Chronic adrenalectomy (ADX) causes a gradual and selective loss of granule cells in the dentate gyrus (DG) of the rat.Here, we administered replacement corticosterone to rats beginning 10wk after ADX. We then tested them ...
  • Milstein, Jean A.; Elnabawi, Ahmed; Vinish, Monika; Swanson, Thomas; Enos, Jennifer K.; Bailey, Aileen M.; Kolb, Bryan; Frost, Douglas O. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Maryland School of MedicineSt. Mary's College of MarylandUniversity of Lethbridge, 2013)
    Antipsychotic drugs are increasingly used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of early life antipsychotic drug treatment. Most ...
  • Gibb, Robbin L.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2004Arts and ScienceDepartment of Neuroscience, 2004)
    Brain damage in the first week of life is behaviorally and anatomically devastating for a rat. I investigated the use of pre- and/or postnatal experience as interventions that might improve the outcomes in rats with ...
  • Kolb, Bryan; Gibb, Robbin L. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2015)
    We review the plastic changes of the prefrontal cortex of the rat in response to a wide range of experiences including sensory and motor experience, gonadal hormones, psychoactive drugs, learning tasks, stress, social ...
  • Gibb, Robbin L.; Gonzalez, Claudia L. R.; Kolb, Bryan (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2014)
    Birth is a particularly vulnerable time for acquiring brain injury. Unfortunately, very few treatments are available for those affected. Here we explore the effectiveness of prenatal intervention in an animal model of early ...
  • Kovalchuk, Anna; Mychasiuk, Richelle; Muhammad, Arif; Hossain, Shakhawat; Ilnytskyy, Yaroslav; Ghose, Abhijit; Kirkby, Charles; Ghasroddashti, Esmaeel; Kolb, Bryan; Kovalchuk, Olga (Frontiers MediaArts and ScienceDepartment of NeuroscienceDepartment of Biological SciencesUniversity of LethbridgeAlberta Epigenetics NetworkUniversity of CalgaryAlberta Health ServicesCanadian Institute for Advanced Research, 2016)
    Irradiated cells can signal damage and distress to both close and distant neighbors that have not been directly exposed to the radiation (naïve bystanders). While studies have shown that such bystander effects occur in the ...
  • Morris, Renee; Whishaw, Ian Q. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2016)
    Spinal cord injury and repair is a dynamic field of research. The development of reliable animal models of traumatic spinal cord injury has been invaluable in providing a wealth of information regarding the pathological ...
  • Schwindel, C. Daniela; Navratilova, Zaneta; Ali, Karim; Tatsuno, Masami; McNaughton, Bruce L. (Society for NeuroscienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of CaliforniaNeuroelectronic Research Flanders, 2016)
    The hippocampus is thought to contribute to episodic memory by creating, storing, and reactivating patterns that are unique to each experience, including different experiences that happen at the same location. Hippocampus ...
  • Stone, Scott A.; Tata, Matthew S. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2017)
    Many salient visual events tend to coincide with auditory events, such as seeing and hearing a car pass by. Information from the visual and auditory senses can be used to create a stable percept of the stimulus. Having ...
  • Burke, Candace J.; Kisko, Theresa M.; Swiftwolfe, Hilarie; Pellis, Sergio M.; Euston, David R. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgePhilipps-University of Marburg, 2017)
    Rat ultrasonic vocalizations have been suggested to be either a byproduct of physical movement or, in the case of 50-kHz calls, a means to communicate positive affect. Yet there are up to 14 distinct types of 50-kHz calls, ...
  • Gonzalez, Claudia L. R.; Li, Fangfang; Mills, Kelly J.; Rosen, Nicole; Gibb, Robbin L. (Frontiers MediaArts and ScienceDepartment of Kinesiology and Physical EducationDepartment of PsychologyDepartment of NeuroscienceUniversity of LethbridgeUniversity of Manitoba, 2014)
    Degree of lateralization for grasping predicts the maturity of the language production system in young, typically-developing children. In this report we provide compelling evidence for the relationship between right hand ...
  • Sparks, Fraser T.; Lehmann, Hugo; Hernandez, Khadaryna; Sutherland, Robert J. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeTrent University, 2011)
    Damage to the hippocampus (HPC) using the excitotoxin N-methyl-D-aspartate (NMDA) can cause retrograde amnesia for contextual fear memory. This amnesia is typically attributed to loss of cells in the HPC. However, NMDA ...