Browsing Faculty Research and Publications by Title

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  • Kolb, Bryan; Muhammad, Arif (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2014)
    A fundamental property of the brain is its capacity to change with a wide variety of experiences, including injury. Although there are spontaneous reparative changes following injury, these changes are rarely sufficient ...
  • Lansink, Carien S.; Goltstein, Pieter M.; Lankelma, Jan V.; McNaughton, Bruce L.; Pennartz, Cyriel M. A. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of AmsterdamUniversity of Lethbridge, 2009)
    Associating spatial locations with rewards is fundamental to survival in natural environments and requires the integrity of the hippocampus and ventral striatum. In joint multineuron recordings from these areas, ...
  • Proft, Juliane; Faraji, Jamshid; Robbins, Jerrah C.; Zucchi, Fabiola C. R.; Zhao, Xiaoxi; Metz, Gerlinde A. S.; Braun, Janice E. A. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of CalgaryUniversity of LethbridgeGolestan University of Medical Sciences, 2011)
    Parkinson’s disease (PD) is a common neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra and the aggregation of a-synuclein into Lewy bodies. Existing therapies address motor ...
  • Hehar, Harleen; Yeates, Keith; Kolb, Bryan; Esser, Michael J.; Mychasiuk, Richelle (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of CalgaryUniversity of Lethbridge, 2015)
    Impulsivity and poor executive control have been implicated in the pathogenesis of many developmental and neuropsychiatric disorders. Similarly, concussions/mild traumatic brain injuries (mTBI) have been associated with ...
  • Thomas, Brittany L.; Karl, Jenni M.; Whishaw, Ian Q. (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2015)
    The Dual Visuomotor Channel Theory proposes that visually guided reaching is a composite of movements, a Reach that advances the hand to contact the target and a Grasp that shapes the digits for target purchase. The theory ...
  • Nie, Yimin; Fellous, Jean-Marc; Tatsuno, Masami (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of Arizona, 2014)
    The characterization of functional network structures among multiple neurons is essential to understanding neural information processing. Information geometry (IG),a theory developed for investigating a space of probability ...
  • Nie, Yimin; Fellous, Jean-Marc; Tatsuno, Masami (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of Arizona, 2014)
    The characterization of functional network structures among multiple neurons is essential to understanding neural information processing .Information geometry (IG) ,a theory developed for investigating a space of probability ...
  • Wylie, Douglas R.; Gutierrez-Ibanez, Cristian I.; Iwaniuk, Andrew N. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of AlbertaTechnische Universität MünchenUniversity of Lethbridge, 2015)
    The comparative anatomy of sensory systems has played a major role in developing theories and principles central to evolutionary neuroscience. This includes the central tenet of many comparativestudies, the principle of ...
  • Wilber, Aaron A.; Clark, Benjamin J.; Forster, Tyler C.; Tatsuno, Masami; McNaughton, Bruce L. (Society for NeuroscienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2014)
    Navigation requires coordination of egocentric and allocentric spatial reference frames and may involve vectorial computations relative to landmarks. Creation of are presentation of target heading relative to landmarks ...
  • Erickson, Zachary T.; Falkenberg, Erin A.; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2014)
    The consumption of artificial food dye (AFD) during childhood and adolescence has been linked to behavioural changes, such as hyperactivity. It is possible that the vulnerability to AFDs is modified by prenatal stress. ...
  • Zucchi, Fabiola C. R.; Yao, Youli; Ilnytskyy, Yaroslav; Robbins, Jerrah C.; Soltanpour, Nasrin; Kovalchuk, Igor; Kovalchuk, Olga; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeUniversity of Mato Grosso State, 2014)
    Prenatal stress (PS) represents a critical variable affecting lifetime health trajectories, metabolic and vascular functions. Beneficial experiences may attenuate the effects of PS and its programming of health outcomes ...
  • Kovalchuk, Anna; Mychasiuk, Richelle; Muhammad, Arif; Hossain, Shakhawat; Ilnytskyy, Slava; Ghose, Abhijit; Kirby, Charles; Ghasroddashti3, Esmaeel; Kovalchuk, Olga; Kolb, Bryan (Impact JournalsArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeAlberta Health ServicesUniversity of CalgaryAlberta Epigenetics NetworkCanadian Institute for Advanced Research, 2016)
    Radiation therapy can not only produce effects on targeted organs, but can also influence shielded bystander organs, such as the brain in targeted liver irradiation. The brain is sensitive to radiation exposure, and ...
  • Schwindel, C. Daniela; Ali, Karim; McNaughton, Bruce L.; Tatsuno, Masami (Society for NeuroscienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2014)
    Characterization of synaptic connectivity is essential to understanding neural circuit dynamics. For extracellularly recorded spike trains, indirect evidence for connectivity can be inferred from short-latency peaks in the ...
  • Ivan, Victorita E.; Banks, Parker J.; Goodfellow, Kris; Gruber, Aaron J. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2018)
    The propensity of animals to shift choices immediately after unexpectedly poor reinforcement outcomes is a pervasive strategy across species and tasks. We report here on the memory supporting such lose-shift responding in ...
  • Lehmann, Hugo; Sparks, Fraser T.; Spanswick, Simon C.; Hadikin, Crystal; McDonald, Robert J.; Sutherland, Robert J. (Cold Spring Harbor Laboratory PressArts and ScienceDepartment of NeuroscienceTrent UniversityUniversity of Lethbridge, 2009)
    We present evidence that certain learning parameters can make a memory, even a very recent one, become independent of the hippocampus. We confirm earlier findings that damage to the hippocampus causes severe retrograde ...
  • Gomez-Lopez, Nardhy; Tanaka, Satomi; Zaeem, Zoya; Metz, Gerlinde A. S.; Olson, David M. (Biomed Central LtdArts and ScienceDepartment of NeuroscienceUniversity of AlbertaUniversity of Lethbridge, 2013)
    Background: Parturition has been widely described as an immunological response; however, it is unknown how this is triggered. We hypothesized that an early event in parturition is an increased responsiveness of ...
  • Zucchi, Fabiola C. R.; Yao, Youli; Ward, Isaac D.; Ilnytskyy, Yaroslav; Olson, David M.; Benzies, Karen; Kovalchuk, Igor; Kovalchuk, Olga; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceDepartment of Biological SciencesUniversity of LethbridgeUniversity of Mato Grosso StateUniversity of AlbertaUniversity of Calgary, 2013)
    The gestational state is a period of particular vulnerability to diseases that affect maternal and fetal health. Stress during gestation may represent a powerful influence on maternal mental health and offspring brain ...
  • Christie, Gregory J.; Cook, Charles M.; Ward, Brian J.; Tata, Matthew S.; Sutherland, Janice; Sutherland, Robert J.; Saucier, Deborah M. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeSimon Fraser UniversityUniversity of Ontario Institute of Technology, 2013)
    This study investigated how both sex and individual differences in a mental rotation test (MRT) influence performance on working memory (WM). To identify the neural substrate supporting these differences, brain electrical ...
  • Gutierrez-Ibanez, Cristian I.; Iwaniuk, Andrew N.; Moore, Bret A.; Fernandez-Juricic, Esteban; Corfield, Jeremy R.; Krilow, Justin M.; Kolominsky, Jeffrey; Wylie, Douglas R. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of AlbertaUniversity of LethbridgePurdue University, 2014)
    Two main models have been proposed to explain how the relative size of neural structures varies through evolution. In the mosaic evolution model, individual brain structures vary in size independently of each other, whereas ...
  • Sacrey, Lori-Ann Rosalind; Clark, Callie Anne Marie; Whishaw, Ian Q. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2009)
    Parkinson’s disease (PD) results in movement and sensory impairments that can be reduced by familiar music. At present, it is unclear whether the beneficial effects of music are limited to lessening the bradykinesia of ...