Browsing Faculty Research and Publications by Issue Date

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  • Gibb, Robbin L.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2001Arts and ScienceDepartment of Neuroscience, 2001)
    The current work explores the therapeutic potential of experiential treatments for enhancing functional recovery and anatomical change after early brain damage. Normal rats and rats with perinatal cortical lesions (P2 or ...
  • Gibb, Robbin L.; University of Lethbridge. Faculty of Arts and Science (Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2004Arts and ScienceDepartment of Neuroscience, 2004)
    Brain damage in the first week of life is behaviorally and anatomically devastating for a rat. I investigated the use of pre- and/or postnatal experience as interventions that might improve the outcomes in rats with ...
  • Lansink, Carien S.; Goltstein, Pieter M.; Lankelma, Jan V.; McNaughton, Bruce L.; Pennartz, Cyriel M. A. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of AmsterdamUniversity of Lethbridge, 2009)
    Associating spatial locations with rewards is fundamental to survival in natural environments and requires the integrity of the hippocampus and ventral striatum. In joint multineuron recordings from these areas, ...
  • Lehmann, Hugo; Sparks, Fraser T.; Spanswick, Simon C.; Hadikin, Crystal; McDonald, Robert J.; Sutherland, Robert J. (Cold Spring Harbor Laboratory PressArts and ScienceDepartment of NeuroscienceTrent UniversityUniversity of Lethbridge, 2009)
    We present evidence that certain learning parameters can make a memory, even a very recent one, become independent of the hippocampus. We confirm earlier findings that damage to the hippocampus causes severe retrograde ...
  • Sacrey, Lori-Ann Rosalind; Clark, Callie A. M.; Whishaw, Ian Q. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2009)
    Parkinson’s disease (PD) results in movement and sensory impairments that can be reduced by familiar music. At present, it is unclear whether the beneficial effects of music are limited to lessening the bradykinesia of ...
  • Sol, Daniel; Garcia, Nuria; Iwaniuk, Andrew N.; Davis, Katie; Meade, Andrew; Boyle, W. Alice; Szekely, Tamas (Public Library of ScienceArts and ScienceDepartment of NeuroscienceAutonomous University of BarcelonaCentre for Advanced Studies of Blanes-Spanish National Research Council-Spanish National Research CouncilUniversity of LethbridgeUniversity of ReadingUniversity of GlasgowUniversity of Western OntarioUniversity of Bath, 2010)
    Despite important recent progress in our understanding of brain evolution, controversy remains regarding the evolutionary forces that have driven its enormous diversification in size. Here, we report that in passerine ...
  • Kolb, Bryan; Teskey, G. Campbell; Gibb, Robbin L. (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of Calgary, 2010)
    An important development in behavioral neuroscience in the past 20 years has been the demonstration that it is possible to stimulate functional recovery after cerebral injury in laboratory animals. Rodent models of ...
  • Spanswick, Simon C.; Sutherland, Robert J. (Cold Spring Harbor Laboratory PressArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2010)
    Chronic adrenalectomy (ADX) causes a gradual and selective loss of granule cells in the dentate gyrus (DG) of the rat.Here, we administered replacement corticosterone to rats beginning 10wk after ADX. We then tested them ...
  • Corfield, Jeremy R.; Gsell, Anna C.; Brunton, Dianne; Heesy, Christopher P.; Hall, Margaret I.; Acosta, Monica L.; Iwaniuk, Andrew N. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeMassey UniversityMidwestern UniversityUniversity of Auckland, 2011)
    The shift from a diurnal to nocturnal lifestyle in vertebrates is generally associated with either enhanced visual sensitivity or a decreased reliance on vision. Within birds, most studies have focused on differences in ...
  • Proft, Juliane; Faraji, Jamshid; Robbins, Jerrah C.; Zucchi, Fabiola C. R.; Zhao, Xiaoxi; Metz, Gerlinde A. S.; Braun, Janice E. A. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of CalgaryUniversity of LethbridgeGolestan University of Medical Sciences, 2011)
    Parkinson’s disease (PD) is a common neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra and the aggregation of a-synuclein into Lewy bodies. Existing therapies address motor ...
  • Sparks, Fraser T.; Lehmann, Hugo; Hernandez, Khadaryna; Sutherland, Robert J. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeTrent University, 2011)
    Damage to the hippocampus (HPC) using the excitotoxin N-methyl-D-aspartate (NMDA) can cause retrograde amnesia for contextual fear memory. This amnesia is typically attributed to loss of cells in the HPC. However, NMDA ...
  • Spanswick, Simon C.; Lehmann, Hugo; Sutherland, Robert J. (Hindawi PublishingArts and ScienceDepartment of NeuroscienceUniversity of CalgaryTrent UniversityUniversity of Lethbridge, 2011)
    Long-term adrenalectomy (ADX) results in an extensive and specific loss of dentate gyrus granule cells in the hippocampus of adult rats. This loss of granule cells extends over a period of weeks to months and ultimately ...
  • Babenko, Olena M.; Golubov, Andrey; Ilnytskyy, Yaroslav; Kovalchuk, Igor; Metz, Gerlinde A. S. (Public Library of ScienceArts and ScienceDepartment of Biological SciencesCanadian Centre for Behavioural NeuroscienceUniversity of LethbridgeUniversity of Calgary, 2012)
    Stress represents a critical influence on motor system function and has been shown to impair movement performance. We hypothesized that stress-induced motor impairments are due to brain-specific changes in miRNA and ...
  • Navratilova, Zaneta; Hoang, Lan T.; Schwindel, C. Daniela; Tatsuno, Masami; McNaughton, Bruce L. (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of Arizona, 2012)
    When rodents engage in irregular foraging in an open-field environment, hippocampal principal cells exhibit place-specific firing that is statistically independent of the direction of traverse through the place field. ...
  • Gruber, Aaron J.; McDonald, Robert J. (Frontiers MediaArts and ScienceDepartment of NeuroscienceUniversity of Lethbridge, 2012)
    Motivated behavior exhibits properties that change with experience and partially dissociate among a number of brain structures. Here, we review evidence from rodent experiments demonstrating that multiple brain systems ...
  • Gutierrez-Ibanez, Cristian I.; Iwaniuk, Andrew N.; Lisney, Thomas J.; Faunes, Macarena; Marin, Gonzalo J.; Wylie, Douglas R. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of AlbertaUniversity of LethbridgeUniversidad de ChileUniversidad Finis Terrae, 2013)
    In birds, there is a retinofugal projection from the brain to the retina originating from the isthmo optic nucleus (ION) in the midbrain. Despite a large number of anatomical, physiological and histochemical studies, the ...
  • Gomez-Lopez, Nardhy; Tanaka, Satomi; Zaeem, Zoya; Metz, Gerlinde A. S.; Olson, David M. (Biomed Central LtdArts and ScienceDepartment of NeuroscienceUniversity of AlbertaUniversity of Lethbridge, 2013)
    Background: Parturition has been widely described as an immunological response; however, it is unknown how this is triggered. We hypothesized that an early event in parturition is an increased responsiveness of ...
  • Walsh, Stig A.; Iwaniuk, Andrew N.; Knoll, Monja A.; Bourdon, Estelle; Barrett, Paul M.; Milner, Angela C.; Nudds, Robert L.; Abel, Richard L.; Sterpaio, Patricia Dello (Public Library of ScienceArts and ScienceDepartment of NeuroscienceNational Museums of ScotlandUniversity of LethbridgeUniversity of the West of ScotlandNatural History Museum (London, England)University of ManchesterImperial College, LondonUniversity of Abertay Dundee, 2013)
    Extinct animal behavior has often been inferred from qualitative assessments of relative brain region size in fossil endocranial casts. For instance, flight capability in pterosaurs and early birds has been inferred from ...
  • Metzler, Megan J.; Saucier, Deborah M.; Metz, Gerlinde A. S. (Frontiers Research FoundationArts and ScienceDepartment of NeuroscienceUniversity of LethbridgeUniversity of Ontario Institute of Technology, 2013)
    Aging is associated with deterioration of skilled manual movement. Specifically, aging corresponds with increased reaction time, greater movement duration, segmentation of movement, increased movement variability, and ...
  • Milstein, Jean A.; Elnabawi, Ahmed; Vinish, Monika; Swanson, Thomas; Enos, Jennifer K.; Bailey, Aileen M.; Kolb, Bryan; Frost, Douglas O. (Public Library of ScienceArts and ScienceDepartment of NeuroscienceUniversity of Maryland School of MedicineSt. Mary's College of MarylandUniversity of Lethbridge, 2013)
    Antipsychotic drugs are increasingly used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of early life antipsychotic drug treatment. Most ...