Show simple item record

dc.contributor.supervisor Gruber, Aaron J.
dc.contributor.supervisor Euston, David R.
dc.contributor.author Hashemnia, Saeedeh
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2019-09-05T20:07:05Z
dc.date.available 2019-09-05T20:07:05Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10133/5550
dc.description.abstract The Anterior Cingulate Cortex (ACC) encodes many decision variables, including effort and reward. This region contains dense dopamine innervations and communicates with several brain regions known to participate in motivation. Lesion of the rat ACC and administration of d-amphetamine (AMPH), which increases extracellular catecholamines, affect choice behaviours. Here, I first investigated neural encoding in rat ACC in a binary choice task with varying amounts of effort and reward. Second, I examined the effects of AMPH on the neural encoding of task-relevant information. In addition to path, effort, and reward, I found that ACC neurons encode the utility. AMPH appeared to significantly disturb this information by decreasing reward encoding and utility signaling. Moreover, low-dose AMPH decreases population state-space volume and variations in neural trajectories; whereas, higher concentrations increase both. Our results thus demonstrate that the ACC is involved in processing the value of the ongoing action and AMPH impairs this function. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : Universtiy of Lethbridge, Department of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Anterior Cingulate Cortex en_US
dc.subject Decision-making en_US
dc.subject Amphetamine en_US
dc.subject Effort-reward utility en_US
dc.subject Electrophysiology en_US
dc.subject Dissertations, Academic en_US
dc.title The encoding of utility and its modulation by psychostimulants in rat anterior cingulate cortex en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Ph.D en_US
dc.proquest.subject 0317 en_US
dc.proquest.subject 0347 en_US
dc.proquest.subject 0419 en_US
dc.proquestyes Yes en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record