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dc.contributor.supervisor McNaughton, Bruce L.
dc.contributor.author Torry, Megan E.
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2019-06-19T18:44:05Z
dc.date.available 2019-06-19T18:44:05Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10133/5412
dc.description.abstract Mechanisms of learning and memory influence brain connectivity. Hippocampal outflow targets the ipsilateral retrosplenial cortex (RSC) and thus influences plasticity in the neocortex. Evidence from fixed tissue suggests that hippocampal lesions prevent the increase in dendritic spines due to an enrichment environment; however, may prevent observation of a larger effect on synaptic turnover across time. Longitudinal two-photon microscopy was used to compare specific ipsilateral and contralateral RSC locations in vivo, before and after enrichment. Consolidation theory predicts that in the absence of one hippocampus the ipsilateral RSC will undergo asymmetry in plasticity following enrichment exposure. In both hemispheres, synaptic turnover persists during home-cage housing with a slight transient increase following transfer to enrichment. There was greater axon growth and a lasting ~7% increase in spine density in the RSC ipsilateral to the lesion. Irregularities in transgenic mouse genetics, and particulars regarding the functionality between pre and post-synaptic elements remain enigmatic. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science)
dc.subject environmental enrichment en_US
dc.subject Axon boutons en_US
dc.subject Dendritic spines en_US
dc.subject In vivo imaging en_US
dc.subject Two photon microscopy en_US
dc.title In Vivo Imaging of Experience-Dependent Plasticity in the Retrosplenial Cortex Following Unilateral Hippocampal Lesions en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters en_US
dc.proquest.subject Neurosciences [0317] en_US
dc.proquest.subject Behavioral sciences [0602] en_US
dc.proquest.subject Cognitive psychology [0633] en_US
dc.proquestyes Yes en_US
dc.embargo No en_US


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