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dc.contributor.author Kovalchuk, Anna
dc.contributor.author Mychasiuk, Richelle
dc.contributor.author Muhammad, Arif
dc.contributor.author Hossain, Shakhawat
dc.contributor.author Ilnytskyy, Slava
dc.contributor.author Ghose, Abhijit
dc.contributor.author Kirby, Charles
dc.contributor.author Ghasroddashti3, Esmaeel
dc.contributor.author Kovalchuk, Olga
dc.contributor.author Kolb, Bryan
dc.date.accessioned 2019-01-23T21:26:27Z
dc.date.available 2019-01-23T21:26:27Z
dc.date.issued 2016
dc.identifier.citation Kovalchuk, A., Mychasiuk, R., Muhammad, A., Hossain, S., Ilnytskyy, S., Ghose, A.,...Kolb. B. (2016). Liver irradiation causes distal bystander effects in the rat brain and affects animal behavior. Oncotarget, 7(4), 4385-4398. https://doi.org/10.18632/oncotarget.6596 en_US
dc.identifier.uri https://hdl.handle.net/10133/5273
dc.description Sherpa Romeo blue journal. Open access: Creative Commons Attribution 3.0 LIcense (CC BY 3.0) applies. en_US
dc.description.abstract Radiation therapy can not only produce effects on targeted organs, but can also influence shielded bystander organs, such as the brain in targeted liver irradiation. The brain is sensitive to radiation exposure, and irradiation causes significant neurocognitive deficits, including deficits in attention, concentration, memory, and executive and visuospatial functions. The mechanisms of their occurrence are not understood, although they may be related to the bystander effects. We analyzed the induction, mechanisms, and behavioural repercussions of bystander effects in the brain upon liver irradiation in a well-established rat model. Here, we show for the first time that bystander effects occur in the prefrontal cortex and hippocampus regions upon liver irradiation, where they manifest as altered gene expression and somewhat increased levels of fH2AX. We also report that bystander effects in the brain are associated with neuroanatomical and behavioural changes, and are more pronounced in females than in males. en_US
dc.language.iso en_US en_US
dc.publisher Impact Journals en_US
dc.subject Radiation therapy en_US
dc.subject Brain en_US
dc.subject Neuroanatomy en_US
dc.subject Behaviour en_US
dc.subject Gene expression en_US
dc.subject Bystander effects en_US
dc.subject Rat brain en_US
dc.subject Bystander organs
dc.subject Liver irradiation
dc.subject.lcsh Radiotherapy
dc.subject.lcsh Animal behavior--Research
dc.subject.lcsh Rats--Behavior
dc.title Liver irradiation causes distal bystander effects in the rat brain and affects animal behavior en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US
dc.publisher.department Department of Neuroscience
dc.description.peer-review Yes en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.institution Alberta Health Services en_US
dc.publisher.institution University of Calgary en_US
dc.publisher.institution Alberta Epigenetics Network en_US
dc.publisher.institution Canadian Institute for Advanced Research en_US


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