Show simple item record Wilber, Aaron A. Clark, Benjamin J. Demecha, Alexis J. Mesina, Lilia Vos, Jessica M. McNaughton, Bruce L. 2018-11-01T18:01:15Z 2018-11-01T18:01:15Z 2014
dc.identifier.citation Wilber, A. A., Clark, B. J., Demecha, A. J., Mesina, L., Vos, J. M., & McNaughton, B. L. (2015). Cortical connectivity maps reveal anatomically distinct areas in the parietal cortex of the rat. Frontiers in Neural Circuits, 8(146). doi: 10.3389/fncir.2014.00146 en_US
dc.description Sherpa Romeo green journal; open access en_US
dc.description.abstract A central feature of theories of spatial navigation involves the representation of spatial relationships between objects in complex environments. The parietal cortex has long been linked to the processing of spatial visual information and recent evidence from single unit recording in rodents suggests a role for this region in encoding egocentric and world-centered frames. The rat parietal cortex can be subdivided into four distinct rostral-caudal andmedial-lateral regions,which includesazonepreviously characterized as secondary visual cortex. At present, very little is known regarding the relative connectivity of these parietal subdivisions. Thus, we set out to map the connectivity of the entire anterior-posterior and medial-lateral span of this region. To do this we used anterograde and retrograde tracers in conjunction with open source neuronal segmentation and tracer detection tools to generate whole brain connectivity maps of parietal inputs and outputs. Our present results show that inputs to the parietal cortex varied significantly along the medial-lateral, but not the rostral-caudal axis. Specifically, retrosplenial connectivity is greater medially, but connectivity with visual cortex, though generally sparse, is more significantlaterally.Finally,basedonconnectiondensity,theconnectivitybetweenparietal cortex and hippocampus is indirect and likely achieved largely via dysgranular retrosplenial cortex. Thus, similar to primates, the parietal cortex of rats exhibits a difference in connectivity along the medial-lateral axis, which may represent functionally distinct areas. en_US
dc.language.iso en_US en_US
dc.publisher Frontiers Media en_US
dc.subject Posterior parietal cortex en_US
dc.subject Retrosplenial cortex en_US
dc.subject Connectivity analysis en_US
dc.subject Automated tracing en_US
dc.subject Cortical flat maps en_US
dc.subject Connectome en_US
dc.subject Segmentation en_US
dc.subject Thalamus en_US
dc.title Cortical connectivity maps reveal anatomically distinct areas in the parietal cortex of the rat en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.institution University of California en_US
dc.publisher.institution University of New Mexico en_US

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