Show simple item record Gidyk, Darryl C. Deibel, Scott H. Hong, Nancy S. McDonald, Robert J. 2018-11-01T16:49:51Z 2018-11-01T16:49:51Z 2015
dc.identifier.citation Gidyk, D. C., Deibel, S. H., Hong, N. S., & McDonald, R. J. (2015). Barriers to developing a valid rodent model of Alzheimer's disease: From behavioral analysis to etiological mechanisms. Frontiers in Neuroscience, 9(245). doi:10.3389/fnins.2015.00245. en_US
dc.description Sherpa Romeo green journal; open access en_US
dc.description.abstract Sporadic Alzheimer’s disease (AD) is the most prevalent form of age-related dementia. As such, great effort has been put forth to investigate the etiology, progression, and underlying mechanisms of the disease. Countless studies have been conducted, however, the details of this disease remain largely unknown. Rodent models provide opportunities to investigate certain aspects of AD that cannot be studied in humans. These animal models vary from study to study and have provided some insight, but no real advancements in the prevention or treatment of the disease. In this Hypothesis and Theory paper, we discuss what we perceive as barriers to impactful discovery in rodent AD research and we offer potential solutions for moving forward. Although no single model of AD is capable of providing the solution to the growing epidemic of the disease, we encourage a comprehensive approach that acknowledges the complex etiology of AD with the goal of enhancing the bidirectional translatability from bench to bedside and vice versa. en_US
dc.language.iso en_US en_US
dc.publisher Frontiers Media en_US
dc.subject Alzheimer's disease en_US
dc.subject Rodent model en_US
dc.subject Aging en_US
dc.subject Hippocampus en_US
dc.subject Memory en_US
dc.subject Cognition en_US
dc.subject Neurodegeneration en_US
dc.subject Dementia en_US
dc.title Barriers to developing a valid rodent model of Alzheimer's disease: from behavioral analysis to etiological mechanisms en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Lethbridge en_US

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