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dc.contributor.supervisor McNaughton, Bruce L.
dc.contributor.author Mao, Dun
dc.date.accessioned 2018-01-23T16:05:49Z
dc.date.available 2018-01-23T16:05:49Z
dc.date.issued 2017
dc.identifier.uri https://hdl.handle.net/10133/5011
dc.description.abstract By virtue of its anatomical connections, the retrosplenial cortex (RSC) is well suited to mediate bidirectional communication between the hippocampal formation and the neocortex. However, what information is encoded in the firing of RSC neurons is largely unclear. I used 2-photon calcium imaging to measure RSC population activity during a goal-directed virtual spatial task that was sometimes complemented by drifting gratings visual stimuli. Over 10% of RSC neurons, mainly in superficial layers, showed place fields with properties similar to CA1 place cells measured in the same task. A distinct subset of neurons (~15%), predominantly in agranular RSC, showed pronounced responses to the visual stimuli. Some of these RSC visual neurons were specifically selective for the speed and direction of visual motion. The results suggest that RSC contains multiple functional cell types distributed differentially across depths and subregions showing responses to external sensory stimulation and internal navigational signals. en_US
dc.description.sponsorship NERF AIHS NSERC en_US
dc.language.iso en en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Hippocampus (Brain) en_US
dc.subject Retrosplenial cortex en_US
dc.subject Spatial navigation en_US
dc.title Neural correlates of sensation and navigation in the retrosplenial cortex en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Ph.D en_US
dc.proquest.subject 0317 en_US
dc.proquestyes Yes en_US
dc.embargo.start 2017-01-10
dc.embargo.end 2017-07-10
dc.embargo Yes en_US


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