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dc.contributor.author Navratilova, Zaneta
dc.contributor.author Hoang, Lan T.
dc.contributor.author Schwindel, C. Daniela
dc.contributor.author Tatsuno, Masami
dc.contributor.author McNaughton, Bruce L.
dc.date.accessioned 2017-04-26T20:50:25Z
dc.date.available 2017-04-26T20:50:25Z
dc.date.issued 2012
dc.identifier.citation Navratilova, Z., Hoang, L. T., Schwindel, C. D., Tatsuno, M., & McNaughton, B. L. (2012). Experience-dependent firing rate remapping generates directional selectivity in hippocampal place cells. Frontiers in Neural Circuits, 6:6. doi:10.3389/fncir.2012.00006 en_US
dc.identifier.uri https://hdl.handle.net/10133/4830
dc.description Sherpa Romeo green journal: open access en_US
dc.description.abstract When rodents engage in irregular foraging in an open-field environment, hippocampal principal cells exhibit place-specific firing that is statistically independent of the direction of traverse through the place field. When the path is restricted to a track, however, in-field rates differ substantially in opposite directions. Frequently, the representations of the track in the two directions are essentially orthogonal. We show that this directionally selective firing is not hard-wired, but develops through experience-dependent plasticity. During the rats' first pass in each direction, place fields were highly directionally symmetric, whereas over subsequent laps, the firing rates in the two directions gradually but substantially diverged. We conclude that, even on a restricted track, place cell firing is initially determined by allocentric position, and only later, the within-field firing rates change in response to differential sensory information or behavioral cues in the two directions. In agreement with previous data, place fields near local cues, such as textures on the track, developed less directionality than place fields on a uniform part of the track, possibily because the local cues reduced the net difference in sensory input at a given point. Directionality also developed in an open environment without physical restriction of the animal's path, when rats learned to run along a specified path. In this case, directionality developed later than on the running track, only after the rats began to run in a stereotyped manner. Although the average population firing rates exhibited little if any change over laps in either direction, the direction-specific firing rates in a given place field were up-or-down-regulated with about equal probability and magnitude, which was independent in the two directions, suggesting some form of competitive mechanism (e.g., LTP/LTD) acting coherently on the set of synapses conveying external information to each cell. en_US
dc.language.iso en_US en_US
dc.publisher Frontiers Research Foundation en_US
dc.subject CA1 en_US
dc.subject CA3 en_US
dc.subject Rate remapping en_US
dc.subject Directional place fields en_US
dc.subject Navigation en_US
dc.subject Path integration en_US
dc.subject.lcsh Rats--Behavior
dc.subject.lcsh Hippocampus (Brain)
dc.title Experience-dependent firing rate remapping generates directional selectivity in hippocampal place cells en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.institution University of Arizona en_US


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