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dc.contributor.author Faraji, Jamshid
dc.contributor.author Soltanpour, Nabiollah
dc.contributor.author Moeeini, Reza
dc.contributor.author Roudaki, Shabnam
dc.contributor.author Soltanpour, Nasrin
dc.contributor.author Abdollahi, Ali-Akbar
dc.contributor.author Metz, Gerlinde A. S.
dc.date.accessioned 2016-11-23T18:13:00Z
dc.date.available 2016-11-23T18:13:00Z
dc.date.issued 2014
dc.identifier.citation Faraji, J., Soltanpour, N., Moeeini, R., Roudaki, S., Soltanpour, N., Abdollahi, A., & Metz, G. A. S. (2014). Topographical disorientation after ischemic mini infarct in the dorsal hippocampus: whispers in silence. Frontiers in Behavioral Neuroscience, 8(261). doi:10.3389/fnbeh.2014.00261 en_US
dc.identifier.uri https://hdl.handle.net/10133/4728
dc.description Sherpa Romeo green journal: open access en_US
dc.description.abstract Silent focal ischemic mini infarcts in the brain are thought to cause no clinically overt symptoms. Some populations of hippocampal cells are particularly sensitive to ischemic events, however, rendering hippocampal functions especially vulnerable to ischemiainduced deficits. The present study investigated whether an otherwise silent ischemic mini infarct in the hippocampus (HPC) can produce impairments in spatial performance in rats. Spatial performance was assessed in the ziggurat task (ZT) using a 10-trial spatial learning protocol for 4 days prior to undergoing hippocampal ischemic lesion or sham surgery. Hippocampal silent ischemia was induced by infusion of endothelin-1 (ET-1), a potent vasoconstrictor, into either the dorsal or the ventral hippocampus (dHPC and vHPC). When tested postoperatively in the ZT using a standard testing protocol for 8 days, rats with hippocampal lesions exhibited no spatial deficit. Although spatial learning and memory in the ZT were not affected by the ET-1-induced silent ischemia, rats with dHPC stroke showed more returns when navigating the ZT as opposed to the vHPC rats. Comparison of region-specific HPC lesions in the present study indicated that dorsal hippocampal function is critically required for topographic orientation in a complex environment. Topographic disorientation as reflected by enhanced return behaviors may represent one of the earliest predictors of cognitive decline after silent ischemic insult that may be potentially traced with sensitive clinical examination in humans. en_US
dc.language.iso en_CA en_US
dc.publisher Frontiers Research Foundation en_US
dc.subject Silent stroke en_US
dc.subject Endotelin-1 en_US
dc.subject Hippocampus en_US
dc.subject Ziggurat task en_US
dc.subject Return behavior en_US
dc.subject Spatial navigation en_US
dc.subject Topographical disorientation en_US
dc.subject Early cognitive decline en_US
dc.title Topographical disorientation after ischemic mini infarct in the dorsal hippocampus: whispers in silence en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.institution Golestan University of Medical Sciences en_US
dc.publisher.institution Babol University of Medical Sciences en_US
dc.publisher.institution Avicenna Institute of Neuroscience en_US


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