Show simple item record Aspden, Joel W. Armstrong, Carol L. Gutierrez-Ibanez, Cristian I. Hawkes, Richard Iwaniuk, Andrew N. Kohl, Tobias Graham, David J. Wylie, Douglas R. 2016-11-08T22:58:23Z 2016-11-08T22:58:23Z 2015
dc.identifier.citation Aspden, J. W., Armstrong, C. L., Gutierrez-Ibanez, C. I., Hawkes, R., Iwaniuk, A. N., Kohl, T. ... Wylie, D. R. (2015). Zebrin II / Aldolase C expression in the cerebellum of the western diamondback rattlesnake (Crotalus atrox). PloS ONE, 10(2), e0117539. doi:10.1371/journal.pone.0177539 en_US
dc.description Sherpa Romeo green journal: open access en_US
dc.description.abstract Aldolase C, also known as Zebrin II (ZII), is a glycolytic enzyme that is expressed in cerebellar Purkinje cells of the vertebrate cerebellum. In both mammals and birds, ZII is expressed heterogeneously, such that there are sagittal stripes of Purkinje cells with high ZII expression (ZII+), alternating with stripes of Purkinje cells with little or no expression (ZII-). The patterns of ZII+ and ZII- stripes in the cerebellum of birds and mammals are strikingly similar, suggesting that it may have first evolved in the stem reptiles. In this study, we examined the expression of ZII in the cerebellum of the western diamondback rattlesnake (Crotalus atrox). In contrast to birds and mammals, the cerebellum of the rattlesnake is much smaller and simpler, consisting of a small, unfoliated dome of cells. A pattern of alternating ZII+ and ZII- sagittal stripes cells was not observed: rather all Purkinje cells were ZII+. This suggests that ZII stripes have either been lost in snakes or that they evolved convergently in birds and mammals. en_US
dc.language.iso en_CA en_US
dc.publisher Public Library of Science en_US
dc.subject Aldolase C en_US
dc.subject Zebrin II en_US
dc.subject ZII expression en_US
dc.subject Western diamondback rattlesnake en_US
dc.subject Cerebellum en_US
dc.subject Purkinje cells en_US
dc.subject ZII stripes en_US
dc.title Zebrin II / Aldolase C expression in the cerebellum of the western diamondback rattlesnake (Crotalus atrox) en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Alberta en_US
dc.publisher.institution Mount Royal University en_US
dc.publisher.institution Technische Universität München en_US
dc.publisher.institution University of Calgary en_US
dc.publisher.institution University of Lethbridge en_US

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