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dc.contributor.author Babenko, Olena M.
dc.contributor.author Golubov, Andrey
dc.contributor.author Ilnytskyy, Yaroslav
dc.contributor.author Kovalchuk, Igor
dc.contributor.author Metz, Gerlinde A. S.
dc.date.accessioned 2016-10-27T02:16:16Z
dc.date.available 2016-10-27T02:16:16Z
dc.date.issued 2012
dc.identifier.citation Babenko, O., Golubov, A., Ilnyskyy, Y., Kovalchuk, I., & Metz, G. A. (2012). Genomic and epigenomic responses to chronic stress involve miRNA-mediated programming. PLoS ONE, 7(1): e29441. doi:10.1371/journal.pone.0029441 en_US
dc.identifier.uri https://hdl.handle.net/10133/4628
dc.description Sherpa Romeo green journal: open access en_US
dc.description.abstract Stress represents a critical influence on motor system function and has been shown to impair movement performance. We hypothesized that stress-induced motor impairments are due to brain-specific changes in miRNA and protein-encoding gene expression. Here we show a causal link between stress-induced motor impairment and associated genetic and epigenetic responses in relevant central motor areas in a rat model. Exposure to two weeks of mild restraint stress altered the expression of 39 genes and nine miRNAs in the cerebellum. In line with persistent behavioural impairments, some changes in gene and miRNA expression were resistant to recovery from stress. Interestingly, stress up-regulated the expression of Adipoq and prolactin receptor mRNAs in the cerebellum. Stress also altered the expression of Prlr, miR-186, and miR-709 in hippocampus and prefrontal cortex. In addition, our findings demonstrate that miR-186 targets the gene Eps15. Furthermore, we found an age-dependent increase in EphrinB3 and GabaA4 receptors. These data show that even mild stress results in substantial genomic and epigenomic changes involving miRNA expression and associated gene targets in the motor system. These findings suggest a central role of miRNA-regulated gene expression in the stress response and in associated neurological function. en_US
dc.language.iso en_CA en_US
dc.publisher Public Library of Science
dc.subject Motor system function en_US
dc.subject Genomic changes en_US
dc.subject Eipgenomic changes en_US
dc.subject miRNA expression en_US
dc.subject Stress en_US
dc.subject Gene expression en_US
dc.subject Motor impairments en_US
dc.subject Behavioural impairments en_US
dc.title Genomic and epigenomic responses to chronic stress involve miRNA-mediated programming en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US
dc.publisher.department Canadian Centre for Behavioural Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.institution University of Calgary en_US


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