Browsing Kovalchuk, Olga by Subject "Breast cancer"

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  • Altered radiation responses of breast cancer cells resistant to hormonal therapy 
    Luzhna, Lidiya; Lykkesfeldt, Anne E.; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeDanish Cancer Society Research Center, 2015)
    Endocrine therapy agents (the selective estrogen receptor (ER) modulators such as tamoxifen or the selective ER down-regulators such as ICI 182,780) are key treatment regimens for hormone receptor-positive breast cancers. ...
  • Circadian disruption and breast cancer: an epigenetic link? 
    Kochan, David Z.; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2015)
    Breast cancer is already the most common malignancy affecting women worldwide, and evidence is mounting that breast cancer induced by circadian disruption (CD) is a warranted concern. Numerous studies have investigated ...
  • Genome-wide profiling of transfer RNAs and their role as novel prognostic markers for breast cancer 
    Krishnan, Preethi; Ghosh, Sunita; Wang, Bo; Heyns, Mieke; Li, Dongping; Mackey, John R.; Kovalchuk, Olga; Damaraju, Sambasivarao (Nature Publishing GroupArts and ScienceDepartment of Biological SciencesUniversity of AlbertaCross Cancer InstituteUniversity of Lethbridge, 2016)
    Transfer RNAs (tRNAs, key molecules in protein synthesis) have not been investigated as potential prognostic markers in breast cancer (BC), despite early findings of their dysregulation and diagnostic potential. We aim ...
  • Next generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer 
    Krishnan, Preethi; Ghosh, Sunita; Wang, Bo; Li, Dongping; Narasimhan, Ashok; Berendt, Richard; Graham, Kathryn; Mackey, John R.; Kovalchuk, Olga; Damaraju, Sambasivarao (BioMed CentralArts and ScienceDepartment of Biological SciencesUniversity of AlbertaCross Cancer InstituteUniversity of Lethbridge, 2015)
    Background: Prognostication of Breast Cancer (BC) relies largely on traditional clinical factors and biomarkers such as hormone or growth factor receptors. Due to their suboptimal specificities, it is challenging to ...
  • Piwi-interacting RNAs and PIWI genes as novel prognostic markers for breast cancer 
    Krishnan, Preethi; Ghosh, Sunita; Graham, Kathryn; Mackey, John R.; Kovalchuk, Olga; Damaraju, Sambasivarao (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of AlbertaAlberta Health ServicesUniversity of Lethbridge, 2016)
    Piwi-interacting RNAs (piRNAs), whose role in germline maintenance has been established, are now also being classified as post-transcriptional regulators of gene expression in somatic cells. PIWI proteins, central to piRNA ...
  • Towards understanding the breast cancer epigenome: a comparison of genome-wide DNA methylation and gene expression data 
    Singhal, Sandeep K.; Usmani, Nawaid; Michiels, Stefan; Metzger-Filho, Otto; Saini, Kamal S.; Kovalchuk, Olga; Parliament, Matthew (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of AlbertaService de Biostatistique et d'EpidemiologieUniversité Paris-SudHarvard Medical SchoolQuantum Health Analytics SPRLUniversity of LethbridgeCanada Cancer and Aging Research Laboratories Ltd., 2016)
    Until recently, an elevated disease risk has been ascribed to a genetic predisposition, however, exciting progress over the past years has discovered alternate elements of inheritance that involve epigenetic regulation. ...