Browsing Faculty Research and Publications by Subject "Antibiotics"

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  • Coatham, Mackenzie L.; Brandon, Harland E.; Fischer, Jeffrey J.; Schummer, Tobias; Wieden, Hans-Joachim (Oxford University PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of AlbertaUniversity of Lethbridgehttps://doi.org/10.1093/nar/gkv1524, 2016)
    Using a combination of biochemical, structural probing and rapid kinetics techniques we reveal for the first time that the universally conserved translational GTPase (trGTPase) HflX binds to the E-site of the 70S ribosome ...
  • Gzyl, Katherine E.; Wieden, Hans-Joachim (Public Library of ScienceArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridge, 2017)
    Understanding the molecular mechanism of antibiotics that are currently in use is important for the development of new antimicrobials. The tetracyclines, discovered in the 1940s, are a well-establis ...