Browsing Chemistry & Biochemistry by Subject "Reactive oxygen species"

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  • Wang, Zhonghua; Bhattacharya, Akash; White, Tommy; Buffone, Cindy; McCabe, Aine; Nguyen, Laura A.; Shepard, Caitlin N.; Pardo, Sammy; Kim, Baek; Weintraub, Susan T.; Demeler, Borries; Diaz-Griffero, Felipe; Ivanov, Dmitri N. (Cell PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science CenterAlbert Einstein College of MedicineEmory School of MedicineKyunghee UniversityUniversity of Lethbridgehttps://doi.org/10.1016/j.celrep.2018.06.090, 2018)
    SAMHD1 is a dNTP triphosphohydrolase (dNTPase)that impairs retroviral replication in a subset of non-cycling immune cells. Here we show that SAMHD1is a redox-sensitive enzyme and identify threeredox-active cysteines within ...