Browsing Chemistry & Biochemistry by Subject "Analytical ultracentrifugation"

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  • Demeler, Borries (Portland PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1042/BIO04102014, 2019)
    In 1926, the Swedish scientist Theodor Svedberg was awarded the Nobel Prize in Chemistry for his work on a disperse system, and for studying the colloidal properties of proteins. This work was, to a ...
  • Savelyev, Alexey; Gorbet, Gary E.; Henrickson, Amy; Demeler, Borries (Public Library of ScienceArts and ScienceDepartment of Chemistry and BiochemistryUniversity of MontanaAUC SolutionsUniversity of Lethbridgehttps://doi.org/10.1371/journal.pcbi.1007942, 2020)
    Recent advances in instrumentation have moved analytical ultracentrifugation (AUC) closer to a possible validation in a Good Manufacturing Practices (GMP) environment. In order for AUC to be validated for a GMP environment, ...
  • Gorbet, Gary E.; Mohapatra, Subhashree; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1007/s00249-018-1297-z, 2018)
    A framework for the global analysis of multi-speed analytical ultracentrifugation sedimentation velocity experiments is presented. We discuss extensions to the adaptive space–time finite element fitting methods implemented ...
  • Mrozowich, Tyler; Henrickson, Amy; Demeler, Borries; Patel, Trushar R. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of MontanaUniversity of CalgaryUniversity of Albertahttps://doi.org/10.3390/v12020190, 2020)
    Viral infections are responsible for numerous deaths worldwide. Flaviviruses, which contain RNA as their genetic material, are one of the most pathogenic families of viruses. There is an increasing amount of evidence ...
  • Tian, Shaoxiong; Yu, Ge; He, Huan; Zhao, Yu; Liu, Peilu; Marshall, Alan G.; Demeler, Borries; Stagg, Scott M.; Li, Hong (Cell PressArts and ScienceDepartment of Chemistry and BiochemistryFlorida State UniversityUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttp://dx.doi.org/10.1016/j.str.2017.08.002, 2017)
    The Saccharomyces cerevisiae (Sc) R2TP complex affords an Hsp90-mediated and nucleotide-driven chaperone activity to proteins of small ribonucleoprotein particles (snoRNPs). The current lack of structural information on ...
  • Kim, Haram; Brookes, Emre; Cao, Weiming; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryCornell UniversityUniversity of Texas Health Science Center at San AntonioUniversity of Texas at San AntonioUniversity of Lethbridgehttps://doi.org/10.1007/s00249-018-1309-z, 2018)
    Sedimentation velocity experiments performed in the analytical ultracentrifuge are modeled using finite-element solutions of the Lamm equation. During modeling, three fundamental parameters are optimized: the sedimentation ...