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dc.contributor.supervisor McDonald, Robert J.
dc.contributor.author Keeley, Robin J.
dc.date.accessioned 2014-10-10T18:39:16Z
dc.date.available 2014-10-10T18:39:16Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/10133/3532
dc.description.abstract The laboratory rat has been used for over a century, and through directed and accidental mechanisms, different rat strains were developed. This study examined the effect of strain and sex on metrics of brain size and function and in response to amphetamine. In addition to strain and sex, the adolescent period is sensitive to drugs of abuse, such as marijuana. This study also examined the effects of post-pubertal exposure of the psychoactive component of marijuana, Δ9-tetrahydrocannabinol (THC), to males of females of two rat strains. Rats were assessed for developmental and adult differences in brain and behaviour, including alterations in sensitivity to amphetamine. This study also implemented parametric and nonparametric statistical tests. Strain and sex contributed to behavioural and neuroanatomical differences between groups exposed to THC during adolescence, and drug experience in adolescence produced strain- and sex-specific effects. This study highlights the background-dependent effects of THC on brain and behaviour. en_US
dc.language.iso en_CA en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2014 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Brain and behavior en_US
dc.subject Strain en_US
dc.subject Sex en_US
dc.subject THC en_US
dc.subject Rats en_US
dc.subject Drugs of abuse en_US
dc.title The effects of rat strain, sex and THC on brain and behaviour : factors that alter the sensitivity to drugs of abuse en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Ph.D en_US
dc.degree.level PhD
dc.proquest.subject 0602 en_US
dc.proquestyes Yes en_US


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