OPUS: Open Ulethbridge Scholarship
Open ULeth Scholarship (OPUS) is the University of Lethbridge's open access research repository. It contains a collection of materials related to research and teaching produced by the academic community.
Self-archiving your research in OPUS is one way to meet Open Access policies of granting agencies. It is important to retain your final, post-peer-reviewed drafts for submission to OPUS, as this is often the only version publishers will allow to be archived. Click here for information on the U of L Open Access Policy.
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Active transportation and independent mobility of school-aged children and their parents: a multi-site study
(Lethbridge, Alta. : University of Lethbridge, Faculty of Health Sciences, 2023) Hecker, Victoria J.; University of Lethbridge. Faculty of Health Sciences; Larouche, Richard
Active transportation (AT) and independent mobility (IM) are important sources of physical activity for children. This study investigated whether parents’ travel mode to school as a child, current travel mode to work, and parental accompaniment on the trip home from school are associated with their children’s AT and IM. Children in grades 4-6 (n=1699) were recruited from urban, suburban, and rural schools in Vancouver, Ottawa and Trois-Rivières. Parents reported their current travel mode to work, IM, and school travel mode as a child. Children self-reported their IM using Hillman’s six mobility licenses. Multiple imputation was performed to replace missing data. Gender-stratified generalized linear mixed models adjusted for child age, parent respondent’s gender, urbanization, and socioeconomic status were used to examine parental influences on their child’s AT and IM. The older a parent was allowed to travel alone as a child, the less IM their child was allowed. Older children and girls whose parents biked to work or lived in Trois-Rivières had higher IM. Parental accompaniment on the trip home from school was associated with less AT trips. Boys in Vancouver and Trois-Rivières reported more active trips compared to Ottawa, though there was no differences found between Vancouver and Trois-Rivières. No significant association was found between parent travel to school as a child and AT. There were no significant associations found between a parent’s current travel mode to work with IM or AT in multivariable models. This project found that children may have more opportunities for AT if parents allow them to come home from school unaccompanied. Parents who experienced IM later may be more restrictive of their child’s IM. This potential for a generational ‘carry-over’ effect has implications for future interventions to promote IM.
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Don’t let the cat out of the bag: record keeping issues with 2SLGBTQIA+ clients
(Lethbridge, Alta. : University of Lethbridge, Faculty of Education, 2024) Gelineau-Olay, Sydney B.; University of Lethbridge. Faculty of Education; McBride, Dawn L.
This project critiques the generalist ethico-legal tools and regulations for counselling psychologists in terms of their limited ability to protect the privacy and moral rights of closeted 2SLGBTQIA+ clients. A detailed analysis of extant research, legislation, and ethical guidelines is first presented. To compensate for the limited available literature on this topic, a modified form of the Canadian Psychological Association’s (2017a) ethical decision-making model is then applied to a fictionalized case study to indicate the value of an emic, socioculturally contextualized approach to decision-making and recordkeeping. The project concludes with a series of recommendations to mitigate outing risks and enhance the ethicality of recordkeeping outcomes, followed by a draft manuscript to be submitted to a peer-reviewed publication.
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'It was almost... always supposed to be the Indian bar': the American Hotel as a contact zone
(Lethbridge, Alta. : University of Lethbridge, Dept. of History, 2024) Gelinas, Ryley M. G.; University of Lethbridge. Faculty of Arts and Science; Alexander, Kristine
From the early 1960s, the American Hotel in Fort Macleod, Alberta was a space where individuals from the neighbouring Kainai and Piikani reserves interacted. This thesis examines how the American Hotel served as a contact zone between white settlers and other non-Indigenous peoples of Fort Macleod and Blackfoot peoples. Drawing on archival research and thirteen oral history interviews conducted with individuals from Fort Macleod and surrounding areas, this thesis explores (1) the history of the American Hotel as a contact zone and (2) the planning, curation, and reception of the museum exhibition Contact Zone: The American Hotel, which ran at the Galt Museum and Archives in Lethbridge from April to October 2023. Providing additional scholarship to the exhibition, this thesis details the sections of the exhibit and discusses the public reception before concluding with a discussion of colonial haunting in contact zones like the American Hotel.
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A day in the life of Mus musculus: homecage behavioural analysis of a mouse model of Alzheimer disease
(Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2023) Liang, Jiajie; University of Lethbridge. Faculty of Arts and Science; Mohajerani, Majid H.; Cheng, Howard
Traditionally, behavioural research of Alzheimer disease animal models involved specialized experiments that require dedicated apparatus and presence of experimenter. However, experiment apparatus and the interaction between animals and experimenters can influence the behaviours of the animals, and result in difficulty in reproducibility. One recent innovation is to study behaviours of Alzheimer disease mouse model in their homecages. This thesis presents an experiment using automated homecages to observe the homecage behaviours of 5xFAD mouse models over 26 weeks. By measuring daily activity level, circadian rhythm and excursion behaviours, the experiment successfully produces measurements consistent with prior knowledge and provides some further insight in the behaviours of the mouse model. This thesis validates the approach using homecage behaviours as a paradigm for AD animal research.
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The impact of psilocybin and eugenol on brain inflammation in murine models: unraveling cumulative and individual effects
(Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, 2023) Zanikov, Timur; University of Lethbridge. Faculty of Arts and Science; Kovalchuk, Igor; Kovalchuk, Olga
Neuroinflammation represents a unique immune response within the central nervous system, involving glial cells such as microglia and astrocytes. Unlike peripheral inflammation, neuroinflammation affects the blood-brain barrier, glia, and neurons. Various factors can induce neuroinflammation, including surgical procedures, infections, traumatic brain injuries, toxin exposure, and immune dysregulation, involving interactions between multiple cell types and signaling molecules.
Neuroinflammation is a critical factor in various acute and chronic brain diseases. Recent research has emphasized the potential anti-inflammatory properties of naturally occurring compounds from mushrooms and plants. This study aimed to investigate the effects of psilocybin and eugenol, individually and in combination, on neuroinflammation. We used two different models to study the effects of treatment on neuroinflammation.
First, we used lipopolysaccharide (LPS) model to examine if our treatments can prevent an increase in cytokine levels in the brains of mice injected with LPS.
Second, we utilized dextran sulfate sodium (DSS) model to assess the combined anti-inflammatory effects of psilocybin and eugenol. While both psilocybin and eugenol individually displayed anti-inflammatory effects, their combined treatment demonstrated an additive effect on the reduction in neuroinflammation. This study adds to the growing body of evidence supporting the therapeutic potential of psilocybin and eugenol in psychiatric and neurodegenerative inflammatory disorders, with further research needed to understand their underlying mechanisms and clinical efficacy.