Faculty Research and Publications

Recent Submissions

  • Kovalchuk, Anna; Ilnytskyy, Yaroslav; Rodriquez-Juarez, Rocio; Katz, Amanda; Sidransky, David; Kolb, Bryan; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeChampions OncologyUniversity of Calgary, 2017)
    A wide array of central nervous system complications, neurological deficits, and cognitive impairments occur and persist as a result of systemic cancer and cancer treatments. This condition is known as chemo brain and it ...
  • Wang, Bo; Li, Dongping; Sidler, Corinne; Rodriquez-Juarez, Rocio; Singh, Natasha; Heyns, Mieke; Ilnytskyy, Yaroslav; Bronson, Roderick T.; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeQiqihar Medical UniversityThe Dana Farber/Harvard Comprehensive Cancer Center, 2015)
    Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide, and it has been linked to radiation exposure. As a well-defined oncogene, wild-type p53-induced phosphatase 1 (WIP1) plays ...
  • Kochan, David Z.; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2015)
    Breast cancer is already the most common malignancy affecting women worldwide, and evidence is mounting that breast cancer induced by circadian disruption (CD) is a warranted concern. Numerous studies have investigated ...
  • Luzhna, Lidiya; Lykkesfeldt, Anne E.; Kovalchuk, Olga (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeDanish Cancer Society Research Center, 2015)
    Endocrine therapy agents (the selective estrogen receptor (ER) modulators such as tamoxifen or the selective ER down-regulators such as ICI 182,780) are key treatment regimens for hormone receptor-positive breast cancers. ...
  • Kovalchuk, Anna; Mychasiuk, Richelle; Muhammad, Arif; Hossain, Shakhawat; Ilnytskyy, Slava; Ghose, Abhijit; Kirby, Charles; Ghasroddashti3, Esmaeel; Kovalchuk, Olga; Kolb, Bryan (Impact JournalsArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeAlberta Health ServicesUniversity of CalgaryAlberta Epigenetics NetworkCanadian Institute for Advanced Research, 2016)
    Radiation therapy can not only produce effects on targeted organs, but can also influence shielded bystander organs, such as the brain in targeted liver irradiation. The brain is sensitive to radiation exposure, and ...
  • Krishnan, Preethi; Ghosh, Sunita; Graham, Kathryn; Mackey, John R.; Kovalchuk, Olga; Damaraju, Sambasivarao (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of AlbertaAlberta Health ServicesUniversity of Lethbridge, 2016)
    Piwi-interacting RNAs (piRNAs), whose role in germline maintenance has been established, are now also being classified as post-transcriptional regulators of gene expression in somatic cells. PIWI proteins, central to piRNA ...
  • Lezhnina, Ksenia; Kovalchuk, Olga; Zhavoronkov, Alexander A.; Korzinkin, Mikhail B.; Zabolotneva, Anastasia A.; Shegay, Peter V.; Sokov, Dmitry G.; Gaifullin, Nurshat M.; Rusakov, Igor G.; Aliper, Alexander M.; Roumiantsev, Sergey A.; Alekseev, Boris Y.; Borisov, Nikolay M.; Buzdin, Anton A. (Impact JournalsArts and ScienceDepartment of Biological SciencesPathway PharmaceuticalsD. Rogachyov Federal Research Center of Pediatric Hematology, Oncology and ImmunologyUniversity of LethbridgeCanada Cancer and Aging Research Laboratories Ltd.John Hopkins UniversityMoscow Institute of Physics and TechnologyShemyakn-Ovchinnikov Institute of Bioorganic ChemistryP.A. Herzen Moscow Oncological Research InstituteMoscow 1st Oncological HospitalLomonosov Moscow State UniversityRussian Medical Postgraduate AcademyA.I. Burnasyan Federal Medical Biophysical Center, 2014)
    We recently proposed a new bioinformatic algorithm called OncoFinder for quantifying the activation of intracellular signaling pathways. It was proved advantageous for minimizing errors of high-throughput gene expression ...
  • Singhal, Sandeep K.; Usmani, Nawaid; Michiels, Stefan; Metzger-Filho, Otto; Saini, Kamal S.; Kovalchuk, Olga; Parliament, Matthew (Impact JournalsArts and ScienceDepartment of Biological SciencesUniversity of AlbertaService de Biostatistique et d'EpidemiologieUniversité Paris-SudHarvard Medical SchoolQuantum Health Analytics SPRLUniversity of LethbridgeCanada Cancer and Aging Research Laboratories Ltd., 2016)
    Until recently, an elevated disease risk has been ascribed to a genetic predisposition, however, exciting progress over the past years has discovered alternate elements of inheritance that involve epigenetic regulation. ...
  • Krishnan, Preethi; Ghosh, Sunita; Wang, Bo; Heyns, Mieke; Graham, Kathryn; Mackey, John R.; Kovalchuk, Olga; Damaraju, Sambasivarao (Public Library of ScienceArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2016)
    One of the most abundant,yet least explored,classes of RNA is the small nucleolar RNAs (snoRNAs), which are well known for their involvement in post-transcriptional modifications of other RNAs. Although snoRNAs were only ...
  • Paquette, Sarah-Jo; Stanford, Kim; Thomas, James E.; Reuter, Tim (Public Library of ScienceArts and ScienceDepartment of Biological SciencesAlberta Agriculture and ForestryUniversity of Lethbridge, 2018)
    Often Escherichia coli are harmless and/or beneficial bacteria inhabiting the gastrointestinal tract of livestock and humans. However, Shiga toxin-producing E. coli (STEC) have been linked to human disease. Cattle are the ...
  • Buchanan, Cody J.; Webb, Andrew L.; Mutschall, Steven K.; Kruczkiewicz, Peter; Barker, Dillon Oliver Reese; Hetman, Benjamin M.; Gannon, Victor P. J.; Abbott, D. Wade; Thomas, James E.; Inglis, G. Douglas; Taboada, Eduardo N. (Frontiers MediaArts and ScienceDepartment of Biological SciencesUniversity of LethbridgeNational Microbiology Laboratory at LethbridgeLethbridge Research and Development Centre, 2017)
    Campylobacter jejuni is a leading human enteric pathogen worldwide and despite an improved understanding of its biology, ecology, and epidemiology, limited tools exist for identifying strains that are likely to cause ...
  • Faraji, Jamshid; Soltanpour, Nabiollah; Ambeskovic, Mirela; Zucchi, Fabiola C. R.; Beaumier, Pierre; Kovalchuk, Igor; Metz, Gerlinde A. S. (Frontiers MediaArts and ScienceDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeGolestan University of Medical Sciences (GUMS)Babol University of Medical SciencesUniversity of BrasiliaCanAlt Health Laboratories, 2017)
    In a continuously stressful environment, the effects of recurrent prenatal stress (PS) may accumulate across generations and alter stress vulnerability and resilience. Here, we report in female rats that a family history ...
  • Kross, Angela S.E.; Roulet, Nigel T.; Moore, Tim R.; Lafleur, Peter M.; Humphreys, Elyn R.; Seaquist, Jonathan W.; Flanagan, Larry B.; Aurela, Mike (American Geophysical UnionArts and ScienceDepartment of Biological SciencesAgriculture and Agri-Food CanadaMcGill UniversityTrent UniversityCarleton UniversityLund UniversityUniversity of LethbridgeFinnish Meteorological Institute, 2014)
    Ecosystem phenology plays an important role in carbon exchange processes and can be derived from continuous records of carbon dioxide (CO2) exchange data. In this study we examined the potential use of phenological indices ...
  • Petrie, M. D.; Brunsell, N. A.; Vargas, R.; Collins, S. L.; Flanagan, Larry B.; Hanan, N. P.; Litvak, M. E.; Suker, A. E. (American Geophysical UnionArts and ScienceDepartment of Biological SciencesUniversity of WyomingUSGS Colorado Plateau Research StationUniversity of KansasUniversity of DelawareUniversity of New MexicoUniversity of LethbridgeSouth Dakota State UniversityUniversity of Nebraska, 2016)
    In the Great Plains, grassland carbon dynamics differ across broad gradients of precipitation and temperature, yet finer-scale variation in these variables may also affect grassland processes. Despite the importance of ...
  • Mezbahuddin, M.; Grant, R. F.; Flanagan, Larry B. (American Geophysical UnionArts and ScienceDepartment of Biological SciencesAlberta Agriculture and ForestryUniversity of AlbertaUniversity of Lethbridge, 2016)
    Improved predictive capacity of hydrology and surface energy exchange is critical for conserving boreal peatland carbon sequestration under drier and warmer climates. We represented basic processes for water and O2 transport ...
  • Ankutowicz, Eric J.; Laird, Robert A. (WileyArts and ScienceDepartment of Biological SciencesUniversity of Lethbridge, 2018)
    Offspring quality decreases with parental age in many taxa, with offspring of older parents exhibiting reduced life span, reproductive capacity, and fitness, compared to offspring of younger parents. These “parental age ...
  • Laing, Chad R.; Buchanan, Cody J.; Taboada, Eduardo N.; Zhang, Yongxiang; Karmali, Mohamed A.; Thomas, James E.; Gannon, Victor P. J. (BioMed CentralArts and ScienceDepartment of Biological SciencesPublic Health Agency of CanadaUniversity of Lethbridge, 2009)
  • Webb, Andrew L.; Kruczkiewicz, Peter; Selinger, L. Brent; Inglis, G. Douglas; Taboada, Eduardo N. (BioMed CentralArts and ScienceDepartment of Biological SciencesAgriculture and Agri-Food CanadaUniversity of LethbridgePublic Health Agency of Canada, 2015)
    Background Molecular typing methods are critical for epidemiological investigations, facilitating disease outbreak detection and source identification. Study of the epidemiology of the emerging human pathogen Arcobacter ...
  • Wang, Ou; Liang, Guanxiang; McAllister, Tim A.; Plastow, Graham; Stanford, Kim; Selinger, L. Brent; Guan, Le Luo (Public LIbrary of ScienceArts and ScienceDepartment of Biological SciencesUniversity of AlbertaLethbridge Research CentreAlberta Agriculture and ForestryUniversity of Lethbridge, 2016)
    Super-shedder cattle are a major disseminator of E . coli O157:H7 into the environment, and the terminal rectum has been proposed as the primary E . coli O157:H7 colonization site. This study aimed to identify ...
  • Thomas, Dallas K.; Lone, Abdul G.; Selinger, L. Brent; Taboada, Eduardo N.; Uwiera, Richard R.E.; Abbott, D. Wade; Inglis, G. Douglas (Public LIbrary of ScienceArts and ScienceDepartment of Biological SciencesAgriculture and Agri-Food Canada Research CentreUniversity of LethbridgePublic Health Agency of CanadaUniversity of Alberta, 2014)
    Campylobacteriosis incited by C. jejuni is a significant enteric disease of human beings. A person working with two reference strains of C. jejuni National Collection of Type Cultures (NCTC) 11168 developed symptoms ...

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