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dc.contributor.supervisor Mohajerani, Majid H.
dc.contributor.supervisor Sutherland, Robert J.
dc.contributor.author Naghizadeh, Milad
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2021-01-07T16:52:54Z
dc.date.available 2021-01-07T16:52:54Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10133/5819
dc.description.abstract In classic measures of fear induced freezing behavior, animals stop all movement except breathing. Many large-scale recording techniques in modern neuroscience such as wide-field and two-photon fluorescent imaging require animals be in a head-fixed preparation. Here we demonstrate that it is possible to measure freezing behavior in head-fixed mice based on video measurements of motion, the pupillary response, and electromyography of neck muscles. Animals were either conditioned to form an association between a tone (conditioned stimulus; CS) and a footshock (unconditioned stimulus; US) or were presented both tones and footshocks explicitly unpaired. Animals who were conditioned to form an association showed less movement, and a stronger pupil response when presented with the CS. We outline key considerations which are likely important in establishing a strong fear response in a head-fixed preparation. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Dissertations, Academic en_US
dc.subject Fear en_US
dc.subject Fear in animals en_US
dc.subject Emotions in animals en_US
dc.subject Psychology en_US
dc.title The fear conditioned response under head fixation en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters en_US
dc.proquest.subject Neurosciences [0317] en_US
dc.proquest.subject Behavioral sciences [0602] en_US
dc.proquest.subject Behavioral psychology [0384] en_US
dc.proquestyes No en_US


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