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dc.contributor.supervisor Metz, Gerlinde A. S.
dc.contributor.supervisor Montina, Tony
dc.contributor.author Bykowski, Elani Ann
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2020-05-29T21:10:37Z
dc.date.available 2020-05-29T21:10:37Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10133/5734
dc.description.abstract Background: This study aims to determine if a proton nuclear magnetic resonance-based quantitative metabolic profiling approach can identify novel biomarkers in clinically accessible biofluids that are indicative of both the repair processes and treatment efficacy during recovery from traumatic brain injury and spinal cord injury. The main hypotheses of this study are (a) that changes in the metabolic profiles following injury can be correlated to the extent of recovery of patients and (b) that biological pathway analysis will provide an insight into the mechanisms behind the repair process. Methods: Patients with spinal cord injury and traumatic brain injury were recruited through the Foothills Medical Centre in Calgary, Alberta. Urine and blood samples were collected from patients initially and again at 6 months post-injury for NMR spectral acquisition. Impact: Metabolomic analysis provides a window into the pathophysiological processes that underlie the recovery process, with insight for clinical application. en_US
dc.description.sponsorship Canadian Institute of Health Research en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Department of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Metabolomics en_US
dc.subject Nuclear Magnetic Resonance Spectroscopy en_US
dc.subject Biomarkers en_US
dc.subject Brain -- Wounds and injuries en_US
dc.subject Spinal cord -- Wounds and injuries en_US
dc.subject Biochemical markers en_US
dc.subject Magnetic resonance imaging -- Diagnostic use en_US
dc.subject Blood -- Analysis en_US
dc.subject Urine -- Analysis en_US
dc.subject Metabolites -- Research en_US
dc.subject Dissertations, Academic en_US
dc.title Urinary and blood-derived biomarkers indicative of recovery from traumatic brain injury and spinal cord injury en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters en_US
dc.proquest.subject 0317 en_US
dc.proquest.subject 0382 en_US
dc.proquest.subject 0719 en_US
dc.proquestyes Yes en_US


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