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dc.contributor.supervisor Vos, Ken
dc.contributor.author Fawehinmi, Festus
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2020-03-23T15:31:31Z
dc.date.available 2020-03-23T15:31:31Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10133/5700
dc.description.abstract The pharmacokinetics (PK) of doxorubicin (DOX) is characterized by a large degree of inter-individual variation, which translates to unpredictability in the drug toxicity and response profiles from one individual to the next. In this work, we introduce a saturable model of DOX PK with fractal exponents using a population PK approach. The initial one-compartment model was expanded to a two-molecule model of DOX and encapsulated DOX, and a four-molecule, three-compartment model of DOX and its toxic metabolite doxorubicinol (DOL). Using this approach, the kinetic parameters of the molecules were developed by minimizing the weighted percentage variance of individual models. Our model provides interesting insights when testing the effects of some covariates on the PK of the molecules. We notice that factors such as patients' gender, race, body weight and liver impairment influence the elimination PK of DOX and DOL. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Physics and Astronomy en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Cancer -- Chemotherapy en_US
dc.subject Chemotherapy en_US
dc.subject Doxorubicin en_US
dc.subject Drugs -- Toxicology en_US
dc.subject Pharmacokinetics en_US
dc.subject Pharmacology en_US
dc.title Pharmacokinetics of Doxorubicin in cancer chemotherapy en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Physics and Astronomy en_US
dc.degree.level Masters en_US
dc.proquest.subject Oncology [0992] en_US
dc.proquest.subject Pharmaceutical sciences [0572] en_US
dc.proquest.subject Toxicology [0383] en_US
dc.proquestyes Yes en_US


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